SRP6509

Chymotrypsin from human pancreas

≥95% (SDS-PAGE)

• Synonym(s): CLCR, CTRC, CTRC_HUMAN, Caldecrin, Chymotrypsin C, Chymotrypsin-C, ELA 4, Elastase 4, Elastase IV, Serum calcium decreasing factor
• EC Number: 232-671-2
• UNSPSC Code: 12352204
• NACRES: NA.78

Properties

• biological source: human
• Assay: ≥95% (SDS-PAGE)
• form: lyophilized
• mol wt: 25 kDa
• packaging: pkg of 100 μg
• UniProt accession no.: Q99895
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... CTRC(11330)

Description

General description

Chymotrypsin from human pancreas is a serine peptidase and has 241 amino acid residues contained in three polypeptide chains (A chain-13 residues, B chain-131 residues, and C chain-97 residues) linked by disulfide bridges. It is secreted by the pancreas as inactive chymotrypsinogen C. Molecular weight of this enzyme is found to be 25kDa. The pI is 8.75.

Biochem/physiol Actions

Chymotrypsin from human pancreas selectively hydrolyzes peptide bonds on the C-terminal side of tyrosine, phenylalanine, tryptophan and leucine. Loss-of-function mutations in this gene have been associated with increased risk of chronic pancreatitis. It has high activity toward leucyl peptide bonds. The enzyme acts as a co-activator of procarboxypeptidases A1 and A2.

Physical form

Lyophilized as a salt-free solid.

Safety Information

• Pictograms: GHS08,GHS07,GHS09
• Signal Word: Danger
• Hazard Statements: H302,H315,H319,H334,H335,H400
• Precautionary Statements: P261 - P264 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1