SML3823
KCI807
≥98% (HPLC)
Synonym(s):
5,3’-Dihydroxyflavone, 5-Hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-one
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About This Item
Empirical Formula (Hill Notation):
C15H10O4
CAS Number:
Molecular Weight:
254.24
MDL number:
UNSPSC Code:
51111800
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
0.2 mg/mL (DMSO:EtOH (2:1),clear, warmed, clear colorless solution)
storage temp.
room temp
Biochem/physiol Actions
KCI807 is a cell penetrant, selective and potent inhibitor of the androgen receptor (AR)-ELK1 interaction. KCI807 interrupts association of the androgen receptor (AR) with transcription activator ELK1 (ETS family transcription factor ELK1). It potently suppresses growth of enzalutamide-resistant prostate cancer tumor xenografts in rodents.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Rayna Rosati et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 24(24), 6509-6522 (2018-09-07)
Testosterone suppression in prostate cancer is limited by serious side effects and resistance via restoration of androgen receptor (AR) functionality. ELK1 is required for AR-dependent growth in various hormone-dependent and castration-resistant prostate cancer models. The amino-terminal domain of AR docks
The Small Molecule Antagonist KCI807 Disrupts Association of the Amino-Terminal Domain of the Androgen Receptor with ELK1 by Modulating the Adjacent DNA Binding Domain
Molecular Pharmacology, 103(4), 211-220 (2023)
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