SML3400
NVS-ZP7-7
≥98% (HPLC)
Synonym(s):
(S)-3,4-Difluoro-N-(1-(2′-oxo-2′,3′-dihydro-1′H-spiro[piperidine-4,4′-quinazoline]-1-yl)-3-phenylpropan-2-yl)benzamide, NVP-LMU348
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About This Item
Empirical Formula (Hill Notation):
C28H28F2N4O2
Molecular Weight:
490.54
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.
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Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
NVS-ZP7-7 is potent inhibitor of the Notch signaling pathway that induces endoplasmic reticulum (ER) stress and induces apoptosis in T-ALL cell lines. NVS-ZP7-7 is a potent and selective inhibitor of SLC39A7 (ZIP7) zinc transporter that increases ER zinc levels. It appears that inhibition of ZIP7 provided significant protection against ferroptosis.
ZIP7 Inhibitor; potent inhibitor of the Notch signaling pathway that induces endoplasmic reticulum (ER) stress and induces apoptosis in T-ALL cell lines.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Discovery of a ZIP7 inhibitor from a Notch pathway screen
Nature Chemical Biology, 15(2), 179-188 (2019)
Po-Han Chen et al.
Cell death & disease, 12(2), 198-198 (2021-02-21)
Ferroptosis is a newly described form of regulated cell death triggered by oxidative stresses and characterized by extensive lipid peroxidation and membrane damages. The name of ferroptosis indicates that the ferroptotic death process depends on iron, but not other metals
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