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Key Documents

SML3262

Sigma-Aldrich

TG11-77 Hydrochloride

≥98% (HPLC)

Synonym(s):

2-((4,6-dimethylpyridin-2-yl)amino)- N-(2-(2-methyl-lH-indol-3-yl)ethyl)pyrimidine-5-carboxamide Hydrochloride, 2-[(4,6-dimethyl-2-pyridinyl)amino]-N-[2-(2-methyl-1H-indol-3-yl)ethyl]- 5-pyrimidinecarboxamide

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About This Item

Empirical Formula (Hill Notation):
C23H24N6O·HCl
CAS Number:
2550393-38-7
Molecular Weight:
436.94
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

Brain-permeable, potent and selective EP2 receptor antagonist
TG11-77 is a brain-permeable, water soluble, highly potent, and selective EP2 receptor antagonist. TG11-77 suppress inflammatory gene expression induced by EP2 activation in a microglial cell line. TG11-77 is useful for study CNS diseases in rodent models.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000193282
0000193281
0000187662

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Potent, selective, water soluble, brain-permeable EP2 receptor antagonist for use in central nervous system disease models.
Radhika Amaradhi, et al.
Journal of Medicinal Chemistry, 63(3), 1032-1050 (2020)

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