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SML2939

Sigma-Aldrich

S2C3 Dibromide

≥98% (HPLC)

Synonym(s):

CYDE-21 dibromide, N,N′-(Decane-1,10-diyl)bis(9-amino-2,3-dihydro-1H-cyclopenta[b]quinolinium) dibromide

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About This Item

Empirical Formula (Hill Notation):
C34H44N4·2Br
Molecular Weight:
668.55
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

2-8°C

SMILES string

NC1=C2C=CC=CC2=[N+](C3=C1CCC3)CCCCCCCCCC[N+]4=C5CCCC5=C(C6=C4C=CC=C6)N

InChI

1S/C34H42N4/c35-33-25-15-7-9-19-29(25)37(31-21-13-17-27(31)33)23-11-5-3-1-2-4-6-12-24-38-30-20-10-8-16-26(30)34(36)28-18-14-22-32(28)38/h7-10,15-16,19-20,35-36H,1-6,11-14,17-18,21-24H2/p+2

InChI key

MEFIQYBUDHNVHT-UHFFFAOYSA-P

Biochem/physiol Actions

S2C3, an analog of dequalinium, is an HIV-1 fusion inhibitor that specifically binds to the gp41 membrane proximal external region (MPER) of the HIV-1 envelope spike and blocks CD4-induced conformational changes. S2C3 effectively block HIV-1 infection. S2C3 (CYDE-21) is a cationic amphiphilic bolaamphiphile nano-sized vesicles or vesicle-like aggregates suitable to carry antisense oligonucleotides (ASO) into bacterium such as C. difficile.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000206973
0000206972
0000194178
0000194178
0000206972

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HIV-1 fusion inhibitors targeting the membrane-proximal external region of Env spikes
Nature Chemical Biology, 16 (2020)
Cationic amphiphilic bolaamphiphile-based delivery of antisense oligonucleotides provides a potentially microbiome sparing treatment for C. difficile
The Journal of Antibiotics, 71 (2018)

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