SML1211

SMANT hydrochloride

≥98% (HPLC)

• Synonym(s): N-(4-Bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride
• Empirical Formula (Hill Notation): C₁₆H₂₃BrN₂O · HCl
• CAS Number: 1177600-74-6
• Molecular Weight: 375.73
• MDL number: MFCD06620515
• UNSPSC Code: 51111800
• PubChem Substance ID: 329825721
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 1 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: BrC1=CC=C(NC(CCN2CC(C)CC(C)C2)=O)C=C1.Cl
• InChI: 1S/C16H23BrN2O.ClH/c1-12-9-13(2)11-19(10-12)8-7-16(20)18-15-5-3-14(17)4-6-15;/h3-6,12-13H,7-11H2,1-2H3,(H,18,20);1H
• InChI key: XQESCHFXROUCOQ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

SMANT is a Hedgehog pathway antagonist, a Smoothened antagonist that behaves similarly against normal cancer smoothened and the M2 mutant. In a study comparing activities among the currently known smoothened/Hedgehog antagonists, SMANT behaves differently, binding to another Smo site different to that bound by other compounds.

Safety Information

• Pictograms: GHS09
• Hazard Statements: H411
• Precautionary Statements: P273 - P391 - P501
• Hazard Classifications: Aquatic Chronic 2
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable