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Key Documents

SML0946

Sigma-Aldrich

Lacidipine

≥98% (HPLC)

Synonym(s):

3,5-Diethyl 4-{2-[(1E)-3-(tert-butoxy)-3-oxoprop-1-en-1-yl]phenyl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, 4-[2-[(1E)-3-(1,1-Dimethylethoxy)-3-oxo-1-propen-1-yl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3,5-diethyl ester, CID 5311217, GR-43659X, GX-1048

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About This Item

Empirical Formula (Hill Notation):
C26H33NO6
CAS Number:
103890-78-4
Molecular Weight:
455.54
UNSPSC Code:
12352106
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

N1C(=C(C(C(=C1C)C(=O)OCC)c2c(cccc2)\C=C\C(=O)OC(C)(C)C)C(=O)OCC)C

InChI

1S/C26H33NO6/c1-8-31-24(29)21-16(3)27-17(4)22(25(30)32-9-2)23(21)19-13-11-10-12-18(19)14-15-20(28)33-26(5,6)7/h10-15,23,27H,8-9H2,1-7H3/b15-14+

InChI key

GKQPCPXONLDCMU-CCEZHUSRSA-N

Biochem/physiol Actions

Lacidipine is a long-acting calcium antagonist that is used in the management of hypertension.
Lacidipine is a long-acting calcium antagonist that is used in the management of hypertension. Lacidipine is a L-type Ca(2+) channel blocker belonging to 1,4-dihydropyridine class. Also, Lacidipine inhibits ryanodine receptors on the ER membrane that enhances folding, trafficking and lysosomal activity of ERAD (ER-associated degradation) misfolded lysosomal glucocerebrosidase (GS).

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000321252
0000321252
0000090110
0000090109
0000041307

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Hakan Dursun et al.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 21(4), 387-395 (2011-02-19)
Calcium channel blockers are increasingly used for the treatment of hypertension. Menopause and hypertension are both important risk factors for liver damage and several other circulatory abnormalities. The aim of this study was to determine the effects of amlodipine and
Arivozhi Mohan et al.
Journal of AOAC International, 94(6), 1800-1806 (2012-02-11)
A simple isocratic, RP-ultra-performance LC method was developed and validated for the determination of lacidipine, three process impurities formed during synthesis, and three degradation products present in drug substance and the drug product. An efficient chromatographic separation was achieved on
Jan Klimas et al.
Basic & clinical pharmacology & toxicology, 111(4), 279-288 (2012-05-26)
Antihypertensive treatment may reduce prolonged QT duration in hypertension. Generally, the reductions of blood pressure and/or of cardiac mass are believed to be the responsible factors. However, drugs are not equivalent in QT modulation despite similar antihypertensive and antihypertrophic action.
Fluctuation: does blood pressure variability matter?
Lawrence R Krakoff
Circulation, 126(5), 525-527 (2012-07-05)
Ramesh Gannu et al.
International journal of pharmaceutics, 388(1-2), 231-241 (2010-01-12)
The purpose of the present study was to develop and optimize the microemulsion based transdermal therapeutic system for lacidipine (LCDP), a poorly water soluble and low bioavailable drug. The pseudo-ternary phase diagrams were developed for various microemulsion formulations composed of
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