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SML0247

Sigma-Aldrich

Rizatriptan benzoate salt

≥98% (HPLC)

Synonym(s):

MK-462, N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine benzoate salt

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About This Item

Empirical Formula (Hill Notation):
C15H19N5 · C7H6O2
CAS Number:
145202-66-0
Molecular Weight:
391.47
MDL number:
MFCD00866224
UNSPSC Code:
12352200
PubChem Substance ID:
329825257
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: ≥5 mg/mL

storage temp.

room temp

SMILES string

OC(=O)c1ccccc1.CN(C)CCc2c[nH]c3ccc(Cn4cncn4)cc23

InChI

1S/C15H19N5.C7H6O2/c1-19(2)6-5-13-8-17-15-4-3-12(7-14(13)15)9-20-11-16-10-18-20;8-7(9)6-4-2-1-3-5-6/h3-4,7-8,10-11,17H,5-6,9H2,1-2H3;1-5H,(H,8,9)

InChI key

JPRXYLQNJJVCMZ-UHFFFAOYSA-N

Gene Information

human ... HTR1B(3351) , HTR1D(3352)

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Biochem/physiol Actions

Rizatriptan is a serotonin 5HT-1B/1D-receptor agonist used to treat migraine.
Rizatriptan is a serotonin 5HT-1B/1D-receptor agonist.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H360

Precautionary Statements

P201 - P308 + P313

Hazard Classifications

Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
033M4734V
022M4725V

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Tony W Ho et al.
Cephalalgia : an international journal of headache, 32(10), 750-765 (2012-06-20)
Treatment options for children and adolescents with migraine are limited. This study evaluated rizatriptan for the acute treatment of migraine in children and adolescents. Randomized, double-blind, placebo-controlled, parallel-group trial in migraineurs 6-17 years old with unsatisfactory response to nonsteroidal anti-inflammatory
Lidia Savi et al.
The journal of headache and pain, 12(6), 609-615 (2011-08-16)
The objectives of this study are to assess the efficacy and safety of frovatriptan, and rizatriptan in the subgroup of women with menstrually related migraine of a multicenter, randomized, double blind, cross-over study. Each patient received frovatriptan 2.5 mg or rizatriptan
Jeffrey L Seeburger et al.
Headache, 52(1), 57-67 (2011-11-15)
To assess efficacy and tolerability of rizatriptan orally disintegrating tablet (ODT) for treatment of acute migraine in patients using topiramate for migraine prophylaxis. There are limited data from prospective controlled trials demonstrating the benefit of triptans in patients who experience
Eric A Kaiser et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(44), 15439-15449 (2012-11-02)
The neuropeptide calcitonin gene-related peptide (CGRP) plays a critical role in the pathophysiology of migraine. We have focused on the role of CGRP in photophobia, which is a common migraine symptom. We previously used an operant-based assay to show that
Rizatriptan is effective for headache in a patient with meningeal carcinomatosis.
Takeshi Satow et al.
Journal of pain and symptom management, 41(5), e2-e4 (2011-04-05)
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