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SAB5700739

Sigma-Aldrich

Anti-TGFBR2 antibody produced in rabbit

Synonym(s):

AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TGF beta Receptor II, TGFBR2, TGFR-2, TGFbeta-RII

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

64
67

species reactivity

rat, human, mouse

concentration

1.92 mg/ml

technique(s)

immunofluorescence: 1:50-1:200
immunohistochemistry: 1:50-1:200
western blot: 1:500-1:2000

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TGFBR2(7048)

Related Categories

General description

This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 23-280 of human TGFBR2 (NP_003233.4).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Questions

  1. Could Product No. SAB5700739, Anti-TGFBR2 antibody, result in a cross reaction with bovine?

    1 answer
    1. The antibody SAB5700739 has not been specifically tested for cross reaction with bovine. Nevertheless, it's worth noting that there is a 95% homology of the immunogen used to produce the antibody with Bovine TGFBR2 (UniProt E1B702). Generally, with polyclonal antibodies, if there is greater than 85% homology between the protein and the immunogen used to produce the antibody, there is a likelihood of cross reaction.

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