Caspase-3 (CASP3) belongs to the class of cysteine proteases. CASP3 is an executioner caspase, which is cleaved and activated with the help of caspase-8 and caspase-9 initiator caspases. CASP3 is mapped to human chromosome 4q35.1.
Immunogen
The antiserum was produced against synthesized peptide derived from human Caspase 3 around the phosphorylation site of Ser150.
Immunogen Range: 116-165
Biochem/physiol Actions
Caspase-3 (CASP3) can degenerate multiple cellular proteins and results in morphological changes and DNA fragmentation in cells at the time of apoptosis. It participates in the growth stimulation. CASP3 plays a major role in the execution phase of apoptosis.
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
CASP3 gene single-nucleotide polymorphism (rs72689236) and Kawasaki disease in Taiwanese children.
Kuo HC, et al.
Journal of Human Genetics, 56(2), 161?165-161?165 (2011)
Expression levels of cleaved caspase-3 and caspase-3 in tumorigenesis and prognosis of oral tongue squamous cell carcinoma.
Liu PF, et al.
PLoS ONE, 12(7), e0180620-e0180620 (2017)
Caspase 3?mediated stimulation of tumor cell repopulation during cancer radiotherapy.
Huang Q, et al.
Nature Medicine, 17(7), 860?866-860?866 (2011)
Identification of SMURF1 as a possible target for 7q21. 3?22.1 amplification detected in a pancreatic cancer cell line by in?house array?based comparative genomic hybridization.
Rationale: UV light deeply penetrates the dermis, leading to inflammation and cell death with prolonged exposure. This is a major contributor to skin photoaging. In the pharmaceutical field, fibroblast growth factors (FGFs) have gained popularity for enhancing skin quality as
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