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Key Documents

SAB4502884

Sigma-Aldrich

Anti-ELOVL4 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Elongation of very long chain fatty acids protein 4

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 36 kDa

species reactivity

mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
western blot: 1:500-1:1000

NCBI accession no.

Q9GZR5

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ELOV4(6785)

General description

Anti-ELOVL4 antibody detects endogenous levels of total ELOVL4 protein.
The ELOVL4 (elongation of very long chain fatty acids protein 4) gene is mapped to human chromosome 6q14.1. The encoded protein localizes to endoplasmic reticulum. ELOVL4 protein consists of five transmembrane domains, a histidine cluster motif and di-lysine motif at the C-terminus.

Immunogen

The antiserum was produced against synthesized peptide derived from human ELOVL4.

Immunogen Range: 41-90

Biochem/physiol Actions

ELOVL4 (elongation of very long chain fatty acids protein 4) plays an important role in the biosynthesis of very long chain fatty acids (both saturated and unsaturated) in the retina, meibomian gland, skin, testis and brain. Mutation in the gene causes autosomal dominant Stargardt3 macular dystrophy. Variation in ELOVL4 results in spastic quadriplegia, ichthyosis and intellectual disability leading to neuro-ichthyotic disorder.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
3115620

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Dominant Stargardt Macular Dystrophy (STGD3) and ELOVL4.
Logan S and Anderson RE
Advances in Experimental Medicine and Biology, 801, 447-453 (2014)
A novel recessive mutation in the gene ELOVL4 causes a neuro-ichthyotic disorder with variable expressivity.
Mir H
BMC Medical Genetics, 15:25, 1-5 (2014)
Different Mutations in ELOVL4 Affect Very Long Chain Fatty Acid Biosynthesis to Cause Variable Neurological Disorders in Humans.
Agbaga MP
Advances in Experimental Medicine and Biology, 854, 129-135 (2016)

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