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S6647

Sigma-Aldrich

[D-Pro4, D-Trp7,9, Nle11]-Substance P Fragment 4-11

≥95% (HPLC)

Synonym(s):

D-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Nle-NH2

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About This Item

Empirical Formula (Hill Notation):
C58H77N13O10
CAS Number:
89430-34-2
Molecular Weight:
1116.31
MDL number:
MFCD00133834
UNSPSC Code:
12352200
PubChem Substance ID:
24899718

Assay

≥95% (HPLC)

UniProt accession no.

P20366

storage temp.

−20°C

SMILES string

CCCCC(NC(=O)C(CC(C)C)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc3ccccc3)NC(=O)C(Cc4c[nH]c5ccccc45)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C6CCCN6)C(N)=O

InChI

1S/C58H77N13O10/c1-4-5-18-41(51(61)74)65-55(78)45(27-33(2)3)68-57(80)48(30-36-32-64-40-20-12-10-17-38(36)40)71-56(79)46(28-34-14-7-6-8-15-34)69-58(81)47(29-35-31-63-39-19-11-9-16-37(35)39)70-54(77)44(23-25-50(60)73)67-53(76)43(22-24-49(59)72)66-52(75)42-21-13-26-62-42/h6-12,14-17,19-20,31-33,41-48,62-64H,4-5,13,18,21-30H2,1-3H3,(H2,59,72)(H2,60,73)(H2,61,74)(H,65,78)(H,66,75)(H,67,76)(H,68,80)(H,69,81)(H,70,77)(H,71,79)

InChI key

OFDJVNRFKDPBKR-UHFFFAOYSA-N

Gene Information

human ... TAC1(6863)

Biochem/physiol Actions

A potent substance P antagonist

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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G Bredy-Dobreva et al.
Acta physiologica et pharmacologica Bulgarica, 15(3), 10-15 (1989-01-01)
The effects of a new analogue of substance P (SP-A) and its interaction with substance P (SP) were studied in vitro isolated preparations from rabbit renal arteries and rat renal and pulmonary arteries. SP-A in did not affect the resting
Synthesis of substance P antagonists: [D-Pro4, D-Trp7,9,Nle11]-substance P(4-11).
G Köller et al.
Die Pharmazie, 39(1), 65-67 (1984-01-01)
Ruofan Wang et al.
Cell, 184(1), 106-119 (2020-12-18)
The Coronaviridae are a family of viruses that cause disease in humans ranging from mild respiratory infection to potentially lethal acute respiratory distress syndrome. Finding host factors common to multiple coronaviruses could facilitate the development of therapies to combat current

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