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S4939

Sigma-Aldrich

N-Succinyl-Leu-Leu-Val-Tyr-7-amido-4-trifluoromethylcoumarin

proteasome substrate, ≥98% (HPLC), solid

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About This Item

Empirical Formula (Hill Notation):
C40H50N5O10F3
Molecular Weight:
817.85
MDL number:
MFCD03453017
UNSPSC Code:
12352204
PubChem Substance ID:
329824447
NACRES:
NA.32

product name

N-Succinyl-Leu-Leu-Val-Tyr-7-amido-4-trifluoromethylcoumarin, ≥98% (HPLC), solid

Quality Level

200

Assay

≥98% (HPLC)

form

solid

solubility

DMF: 1 mg/mL, clear, colorless to light yellow

storage temp.

−20°C

SMILES string

CC(C)C[C@H](NC(=O)CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)Nc2ccc3c(OC(=O)C=C3C(F)(F)F)c2

InChI

1S/C40H50F3N5O10/c1-20(2)15-28(45-32(50)13-14-33(51)52)37(55)46-29(16-21(3)4)38(56)48-35(22(5)6)39(57)47-30(17-23-7-10-25(49)11-8-23)36(54)44-24-9-12-26-27(40(41,42)43)19-34(53)58-31(26)18-24/h7-12,18-22,28-30,35,49H,13-17H2,1-6H3,(H,44,54)(H,45,50)(H,46,55)(H,47,57)(H,48,56)(H,51,52)/t28-,29-,30-,35-/m0/s1

InChI key

ZSJPCNKJLSJEQF-DWNBPJMTSA-N

Biochem/physiol Actions

Chymotrypsin and multicatalytic endopeptidase complex: proteasome substrate similar to AMC derivative

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mafalda Santos et al.
Frontiers in molecular biosciences, 9, 809985-809985 (2022-05-20)
Serine tRNAs (tRNASer) are frequently overexpressed in tumors and associated with poor prognosis and increased risk of recurrence in breast cancer. Impairment of tRNA biogenesis and abundance also impacts proteome homeostasis, and activates protein quality control systems. Herein, we aimed
Ana Sofia Varanda et al.
RNA biology, 17(1), 135-149 (2019-10-02)
Deregulation of tRNAs, aminoacyl-tRNA synthetases (aaRS) or tRNA modifying enzymes, increase the level of protein synthesis errors (PSE) and are associated with several diseases, but the cause-effect mechanisms of these pathologies remain elusive. To clarify the role of PSE in

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