S1068
SB-215505
solid, >98% (HPLC)
Synonym(s):
6-Chloro-5-methyl-1-5-quinolycarbamoyl-indoline
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About This Item
Empirical Formula (Hill Notation):
C19H16N3OCl
CAS Number:
Molecular Weight:
337.80
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay
>98% (HPLC)
form
solid
color
off-white
solubility
DMSO: soluble ~11 mg/mL at 60 °C
H2O: insoluble
originator
GlaxoSmithKline
storage temp.
2-8°C
SMILES string
Cc1cc2CCN(C(=O)Nc3ccnc4ccccc34)c2cc1Cl
InChI
1S/C19H16ClN3O/c1-12-10-13-7-9-23(18(13)11-15(12)20)19(24)22-17-6-8-21-16-5-3-2-4-14(16)17/h2-6,8,10-11H,7,9H2,1H3,(H,21,22,24)
InChI key
BPVGSWDWIRIUME-UHFFFAOYSA-N
Gene Information
human ... HTR2B(3357)
Biochem/physiol Actions
Selective 5-HT2B serotonin receptor antagonist; 100-fold higher affinity at 2B versus 2C.
Features and Benefits
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Legal Information
Sold for research purposes under agreement from GlaxoSmithKline
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Adam J Isabella et al.
Developmental cell, 53(3), 344-357 (2020-04-18)
Information flow through neural circuits often requires their organization into topographic maps in which the positions of cell bodies and synaptic targets correspond. To understand how topographic map development is controlled, we examine the mechanism underlying targeting of vagus motor
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