Skip to Content
Merck
All Photos(1)

Documents

RAB1073

Sigma-Aldrich

Human Osteocalcin ELISA Kit

for cell culture supernatants, plasma, and serum samples

Synonym(s):

Osteocalcin

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
41116158
NACRES:
NA.32

species reactivity

human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable

input

sample type cell culture supernatant(s)
sample type serum sample(s)
sample type plasma

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.4 ng/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... BGLAP(632)

Related Categories

General description

Osteocalcin (OC/OCN) is a bone-building protein. This γ-carboxylated protein is made up of 49 amino acids and is synthesized by osteoblasts, odontoblasts and hypertrophic chondrocytes. The bone γ-carboxyglutamate protein (BGLAP), that produces OCN is located on human chromosome 1q22.
This ELISA antibody pair detects human Osteocalcin. Other species are not determined.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

Biochem/physiol Actions

Osteocalcin (OC/ OCN) plays a major role in the bone remodeling cycle, affecting bone mineralization. It is considered as a marker of bone formation. OCN guards against the progression of diabetes and the metabolic syndrome.

Other Notes

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

Pictograms

Corrosion
GHS05

Signal Word

Warning

Hazard Statements

H290

Precautionary Statements

P234 - P390

Hazard Classifications

Met. Corr. 1

Storage Class Code

8A - Combustible corrosive hazardous materials

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Comprehensive metabolic characterization of serum osteocalcin action in a large non-diabetic sample
Entenmann L, et al.
Testing, 12(9), e0184721-e0184721 (2017)
Guangwen Jin et al.
FEBS open bio, 8(4), 523-532 (2018-04-11)
Osteoporosis is a progressive bone disease caused by an imbalance between bone resorption and formation. Recently, plasminogen activator inhibitor-1 (PAI-1) was shown to play an important role in bone metabolism using PAI-1-deficient mice. In this study, we evaluated the therapeutic
Analysis of osteocalcin as a candidate gene for type 2 diabetes (T2D) and intermediate traits in Caucasians and African Americans
Das S K, et al.
Disease Markers, 28(5), 281-286 (2010)
Bernhard Bielesz et al.
Scientific reports, 7(1), 17941-17941 (2017-12-22)
Vascular calcification is a component of cardiovascular disease, which is leading cause of death in patients with chronic kidney disease (CKD). A functional assay (T50-test) measuring the propensity of human serum to calcify associates with mortality and cardiovascular events in
Kevin D Cashman et al.
Nutrients, 11(8) (2019-07-31)
Reformulation of bread in terms of salt content remains an important measure to help achieve a reduction in salt intake in the population and for the prevention of hypertension and elevated blood pressure (BP). Our fundamental studies on the reduction
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service