P4855
Poly(ADP-ribose) Polymerase Automodified bovine
solution
Synonym(s):
PARP
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About This Item
form
solution
Application
Positive control for immunoblotting techniques. A streak of M.W. > 116 kDa is detected by immunoblotting, representing PARP modified to various extents by poly(ADP-ribose). Recommended use: 5-20 μl per gel lane.
Other Notes
Partially purified bovine PARP, automodified by the addition of NAD and necessary cofactors.
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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
inhibitor
Product No.
Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Dermal - Aquatic Chronic 3 - Eye Dam. 1 - Repr. 2 - Skin Sens. 1
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Carla O Contreras-Ochoa et al.
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Cancer chemotherapy and pharmacology, 71(5), 1287-1295 (2013-03-13)
Platinum-based chemotherapy is the most common treatment for patients with advanced non-small cell lung cancer (NSCLC). Genetic polymorphisms in the base excision repair (BER) pathway are suspected to influence the response of patients to this type of therapy. In this
Sheng-Yi Yu et al.
Chemico-biological interactions, 203(2), 412-422 (2013-03-26)
Gefitinib, a tyrosine kinase inhibitor of the epidermal growth factor receptor (EGFR), has been used to treat numerous cancers; however, evidence has shown that cancer cells can become resistant to gefitinib during therapy. Here, we report a human proto-oncogene, securin
Tomoharu Osada et al.
Biochemical and biophysical research communications, 434(1), 15-21 (2013-04-04)
We examined the roles of poly(ADP-ribosylation) in chromatin remodeling during the first cell cycle of mouse embryos. Drug-based inhibition of poly(ADP-ribosylation) by a PARP inhibitor, PJ-34, revealed up-regulation of dimethylation of histone H3 at lysine 4 in male pronuclei and
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