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P4761

Sigma-Aldrich

Poly-L-glutamic acid sodium salt

mol wt 15,000-50,000

Synonym(s):

L-Glutamic acid homopolymer sodium salt

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About This Item

CAS Number:
26247-79-0
MDL number:
MFCD00081868
UNSPSC Code:
12352209
NACRES:
NA.25

form

powder

mol wt

15,000-50,000

color

white to off-white

application(s)

detection

storage temp.

−20°C

InChI

1S/C15H23N3O10/c16-7(1-4-10(19)20)13(25)17-8(2-5-11(21)22)14(26)18-9(15(27)28)3-6-12(23)24/h7-9H,1-6,16H2,(H,17,25)(H,18,26)(H,19,20)(H,21,22)(H,23,24)(H,27,28)/t7-,8-,9-/m0/s1

InChI key

BUZMZDDKFCSKOT-CIUDSAMLSA-N

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Application


  • Effect of Micelle-Incorporated Cisplatin With Sizes Ranging From 8 to 40 nm for the Therapy of Lewis Lung Carcinoma.: This research explores the use of micelle-incorporated cisplatin nanoparticles for cancer therapy, highlighting the significance of particle size on therapeutic efficacy. Poly-ʟ-glutamic acid sodium salt is used to improve drug delivery and target specificity (Wang Z et al., 2021).

  • Ternary Polypeptide Nanoparticles with Improved Encapsulation, Sustained Release, and Enhanced In Vitro Efficacy of Carfilzomib.: This paper describes the development of ternary polypeptide nanoparticles, including poly-ʟ-glutamic acid sodium salt, to enhance the encapsulation and release of carfilzomib, an anticancer drug. The study demonstrates improved drug efficacy and controlled release profiles (Agbana P et al., 2020).

  • Polymeric Core-Shell Nanoparticles Prepared by Spontaneous Emulsification Solvent Evaporation and Functionalized by the Layer-by-Layer Method.: This research focuses on the preparation of polymeric core-shell nanoparticles using a spontaneous emulsification method. Poly-ʟ-glutamic acid sodium salt is used to functionalize these nanoparticles, which can be applied in drug delivery systems (Szczęch M et al., 2020).

  • Co-administration of Combretastatin A4 Nanoparticles and Sorafenib for Systemic Therapy of Hepatocellular Carcinoma.: This study evaluates the combined use of combretastatin A4 nanoparticles and sorafenib for treating liver cancer. Poly-ʟ-glutamic acid sodium salt is employed to enhance the stability and delivery of these nanoparticles, showing promise in improving therapeutic outcomes (Wang Y et al., 2019).

Analysis Note

Molecular weight based on viscosity.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Recently, the benefit of step-wise sequential delivery of fibroblast growth factor-2 (FGF-2) and bone morphogenetic protein-2 from a bioinspired apatite drug delivery system on mouse calvarial bone repair was demonstrated. The thicknesses of the nanostructured poly-l-Lysine/poly-l-Glutamic acid polyelectrolyte multilayer (PEM)

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