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P0119

Sigma-Aldrich

Anti-Purinergic Receptor P2Y14 (extracellular) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-GPR105, Anti-P2YR14

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human, rat

technique(s)

western blot: 1:200 using rat brain and lung lysates, and rat heart membranes

UniProt accession no.

Q15391

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... P2RY14(9934)
rat ... P2ry14(171108)

Immunogen

peptide CIELKSELGRKWHKASN corresponding to residues 172-188 of human P2Y14 extracellular loop.

Target description

P2Y14 belongs to the P2Y receptor family that is part of the G-protein coupled receptor superfamily. P2Y14 is expressed in several tissues including brain, lung, and several cells of hematopoietic origin such as T lymphocytes and dendritic cells. This receptor is apparently involved in chemotaxis, maturation of immature dendritic cells, and neuroimmune regulation.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide.

Reconstitution

Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jennifer Patritti Cram et al.
eLife, 11 (2022-03-22)
Neurofibromatosis type 1 (NF1) is characterized by nerve tumors called neurofibromas, in which Schwann cells (SCs) show deregulated RAS signaling. NF1 is also implicated in regulation of cAMP. We identified the G-protein-coupled receptor (GPCR) P2ry14 in human neurofibromas, neurofibroma-derived SC

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