To determine the effects of continuous combined hormone therapy, tibolone, black cohosh, and placebo on digitized mammographic breast density in postmenopausal women. A prospective, double-blind, placebo-controlled study of 154 postmenopausal women randomized to estradiol 2 mg/norethisterone acetate 1 mg (E2/NETA)
Medroxyprogesterone acetate (MPA) and norethisterone (NET) and its derivatives are widely used in female reproductive therapy, but little is known about their mechanisms of action via steroid receptors in the female genital tract. MPA used as a contraceptive has been
Risk assessment of future breast cancer risk through exposure to sex steroids currently relies on clinical scorings such as mammographic density. Knowledge about the gene expression patterns in existing breast cancer tumors may be used to identify risk factors in
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 20(5), 372-379 (2010-08-21)
To investigate the effects of combined hormone replacement therapy (HRT) and its effective agents on the IGF-1 signaling pathway. To examine the effects of HRT on skeletal muscle in vivo, we utilized pre- and post-intervention samples from a randomized double
To determine the effects of HRT with or without clodronate on bone mineral density (BMD) change and bone turnover markers. Prospective, partly randomized trial. Kuopio University Hospital, Finland. 167 osteoporotic women (61+/-2.7 years; T-score<or=-2.5 SD). Estradiol 2 mg+NETA 1 mg
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