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M4949

Sigma-Aldrich

2′-C-Methylcytidine

≥95% (HPLC), powder

Synonym(s):

2′-C-Methyl Cytidine, NM107

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About This Item

Empirical Formula (Hill Notation):
C10H15N3O5
CAS Number:
20724-73-6
Molecular Weight:
257.24
MDL number:
MFCD02682947
UNSPSC Code:
12352200
PubChem Substance ID:
329817997
NACRES:
NA.77

Assay

≥95% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

H2O: >20 mg/mL

storage temp.

−20°C

SMILES string

C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N2C=CC(N)=NC2=O

InChI

1S/C10H15N3O5/c1-10(17)7(15)5(4-14)18-8(10)13-3-2-6(11)12-9(13)16/h2-3,5,7-8,14-15,17H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,10-/m1/s1

InChI key

PPUDLEUZKVJXSZ-VPCXQMTMSA-N

Biochem/physiol Actions

2′-C-Methylcytidine is a potent inhibitor of the HCV NS5B RNA polymerase. 2′-C-Methylcytidine was the first nucleoside NS5B inhibitor that showed clinical efficacy. 2′-C-Methylcytidine was found to be effective against the 17D vaccine strain of yellow fever virus YFV in cell culture.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Abhilasha Madhvi et al.
Scientific reports, 7(1), 5816-5816 (2017-07-21)
Hepatitis C virus (HCV) is a global pathogen and infects more than 185 million individuals worldwide. Although recent development of direct acting antivirals (DAA) has shown promise in HCV therapy, there is an urgent need for the development of more
Natalie E Netzler et al.
Antimicrobial agents and chemotherapy, 63(6) (2019-03-20)
Globally, hepatitis E virus (HEV) causes significant morbidity and mortality each year. Despite this burden, there are no specific antivirals available to treat HEV patients, and the only licensed vaccine is not available outside China. Ribavirin and alpha interferon are
Natalie E Netzler et al.
Antiviral research, 146, 65-75 (2017-08-02)
Viruses of the Caliciviridae cause significant and sometimes lethal diseases, however despite substantial research efforts, specific antivirals are lacking. Broad-spectrum antivirals could combat multiple viral pathogens, offering a rapid solution when no therapies exist. The RNA-dependent RNA polymerase (RdRp) is
Navaneethan Palanisamy et al.
Pathogens and global health, 112(4), 210-226 (2018-05-11)
Alkhumra hemorrhagic fever virus (AHFV), a relatively new member of the Flaviviruses, was discovered in Saudi Arabia 23 years ago. AHFV is classified in the tick-borne encephalitis virus serocomplex, along with the Kyasanur forest disease virus (KFDV) and tick-borne encephalitis
Myungeun Lee et al.
Scientific reports, 7, 44676-44676 (2017-03-24)
Despite recent advances in curing chronic hepatitis C (CHC), the high economic burden to therapy, viral drug resistance, difficult to treat hepatitis C virus (HCV) genotypes and patient groups are still of concern. To address this unmet medical needs, we

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