I1007
6-(Iodoacetamido)hexanoic acid N-hydroxysuccinimide ester
powder
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About This Item
Empirical Formula (Hill Notation):
C12H17IN2O5
CAS Number:
Molecular Weight:
396.18
MDL number:
UNSPSC Code:
12171500
form
powder
solubility
methanol: 50 mg/mL
DMF: soluble
storage temp.
−20°C
SMILES string
ICC(=O)NCCCCCC(=O)ON1C(=O)CCC1=O
Application
A heterobifunctional cross-linking reagent containing an extended spacer with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5) Second coupling specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 7.5 (7.0-8.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Provides a 9-atom linker.
Caution
The iodoacetyl group is light sensitive.
Certificates of Analysis (COA)
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E S Rector et al.
Journal of immunological methods, 24(3-4), 321-336 (1978-01-01)
A novel procedure for the synthesis of well-defined protein-protein conjugates is described using ovalbumin (OA) and IgG as test proteins. This procedure involves the highly selective and rapid reaction of alkyl halide and sulfhydryl groups, which have been grafted, respectively
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