Elucidating uptake and metabolic fate of dipeptides in CHO cell cultures using (13)C labeling experiments and kinetic modeling: This study delves into the uptake and metabolic processing of dipeptides such as Gly-Tyr in cell cultures, providing insights into their utilization and role in enhancing biopharmaceutical production processes (Naik et al., 2024).
Although tyrosine is considered indispensable during the neonatal period, its poor solubility has limited its inclusion in parenteral amino acid solutions to less than 1% of total amino acids. Dipeptides of tyrosine are highly soluble, have been shown to be
The Journal of nutrition, 126(3), 663-667 (1996-03-01)
Poor solubility hampers the addition of sufficient amounts of free tyrosine to parenteral amino solutions. We investigated the use of a highly soluble synthetic dipeptide, glycyl-L-tyrosine, as a parenteral tyrosine source in 18 male Wistar rats (body weight 180-200 g).
The journal of physical chemistry. B, 110(25), 12419-12426 (2006-06-28)
Voltammetric techniques have been introduced to monitor the formation of gold nanoparticles produced via the reaction of the amino acid glycyl-L-tyrosine with Au(III) (bromoaurate) in 0.05 M KOH conditions. The alkaline conditions facilitate amino acid binding to Au(III), inhibit the
The Journal of nutrition, 129(6), 1161-1166 (1999-06-04)
The purpose of this study was to determine whether the ovine fetus is capable of increased disposal of an amino acid load; if so, would it respond by increased protein synthesis, amino acid catabolism or both? A further purpose of
The American journal of physiology, 267(5 Pt 1), E672-E679 (1994-11-01)
Low tyrosine solubility in total parenteral nutrition (TPN) solutions complicates meeting the aromatic amino acid needs of infants. This study compared the effectiveness of two tyrosine precursors to supply the aromatic amino acid needs of TPN-fed neonatal piglets with a
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