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D9571

Sigma-Aldrich

Dolasetron mesylate hydrate

≥98% (HPLC), powder

Synonym(s):

Anzemet hydrate, Dolasetron methanesulfonate hydrate

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About This Item

Empirical Formula (Hill Notation):
C19H20N2O3 · CH4O3S · xH2O
CAS Number:
Molecular Weight:
420.48 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

H2O: >30 mg/mL

originator

Sanofi Aventis

storage temp.

2-8°C

SMILES string

O.CS(O)(=O)=O.O=C1CN2[C@@H]3C[C@H](C[C@H]2CC1C3)OC(=O)c4c[nH]c5ccccc45

InChI

1S/C19H20N2O3.CH4O3S.H2O/c22-18-10-21-12-5-11(18)6-13(21)8-14(7-12)24-19(23)16-9-20-17-4-2-1-3-15(16)17;1-5(2,3)4;/h1-4,9,11-14,20H,5-8,10H2;1H3,(H,2,3,4);1H2/t11?,12-,13+,14+;;

InChI key

QTFFGPOXNNGTGZ-BHSFMSKKSA-N

Biochem/physiol Actions

Dolasetron mesylate hydrate is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors.

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Sadeq A Quraishi et al.
Journal of clinical anesthesia, 23(4), 297-302 (2011-06-15)
To investigate whether a common single nucleotide polymorphism (SNP), rs10494366, is associated with significant prolongation of the QTc interval following administration of 5-HT(3)-receptor antagonists in the perioperative setting. Post-hoc analysis of deoxyribonucleic acid (DNA) samples and electrocardiographic (ECG) data from
Swen N Piper et al.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 36(3), 173-179 (2008-03-21)
The aim of this study was to evaluate the efficacy of dolasetron and droperidol (DHB) for preventing postoperative nausea and vomiting (PONV) in patients undergoing surgery for prognathism. In a randomised, placebo-controlled, double-blind trial, the efficacy of 12.5 mg dolasetron
John A Shields
AANA journal, 76(1), 41-45 (2008-03-08)
Heart block and Q-Tc interval prolongation have been reported with several agents used in anesthesia, and the US Food and Drug Administration mandates evaluation of the Q-T interval with new drugs. Drug-induced Q-T interval prolongation may precipitate life-threatening arrhythmias, is
D Rüsch et al.
Anaesthesia, 62(8), 810-817 (2007-07-20)
It is not known whether dexamethasone increases the effectiveness of anti-emetics when given to treat postoperative nausea and vomiting (PONV). In a randomised study, 242 patients who were experiencing PONV received dolasetron and placebo, haloperidol and placebo, dolasetron and dexamethasone
Laurel M Adams et al.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 17(9), 1187-1193 (2009-02-12)
The objective of this study was to characterize the impact of casopitant, a novel neurokinin-1 receptor antagonist under investigation for the prevention of postoperative and chemotherapy-induced nausea and vomiting, on the pharmacokinetics of the commonly prescribed 5-hydroxytryptamine receptor 3 receptor

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