B5057
7-Benzyloxy-4-trifluoromethylcoumarin
≥99% (HPLC), solid
Synonym(s):
7-BFC
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About This Item
Empirical Formula (Hill Notation):
C17H11F3O3
Molecular Weight:
320.26
MDL number:
UNSPSC Code:
12161501
PubChem Substance ID:
NACRES:
NA.47
Pricing and availability is not currently available.
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Product Name
7-Benzyloxy-4-trifluoromethylcoumarin, ≥99% (HPLC), solid
Quality Level
Assay
≥99% (HPLC)
form
solid
storage temp.
−20°C
SMILES string
FC(F)(F)C1=CC(=O)Oc2cc(OCc3ccccc3)ccc12
InChI
1S/C17H11F3O3/c18-17(19,20)14-9-16(21)23-15-8-12(6-7-13(14)15)22-10-11-4-2-1-3-5-11/h1-9H,10H2
InChI key
WVKLERKKJXUPIK-UHFFFAOYSA-N
Gene Information
rat ... Maoa(29253) , Maob(25750)
Application
7-Benzyloxy-4-trifluoromethylcoumarin has been used:
- in the SBAD2-3x-AAGLY hepatocyte-like cell (HLC) functional assay to measure the cytochrome P450 3A4 (CYP3A4)-dependent activity
- in O-dealkylation reaction to determine the activity of CYP3A
- to measure the activity of CYP3A-mediated 7-benzyloxy-4-trifluoromethylcoumarin O-debenzylase activity (BFCOD)
Biochem/physiol Actions
Metabolized primarily by cytochrome P450 isozymes CYP1A2 and CYP3A4.
Legal Information
Supplied by Gentest Corp., U.S. Patent Nos. 6,207,404.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Manami Nishiwaki et al.
Scientific reports, 10(1), 17503-17503 (2020-10-17)
Hepatocytes are an important tool for in vitro toxicology testing. In addition to primary cultures, a limited number of immortalized cell lines have been developed. We here describe a new cell line, designated as HepaMN, which has been established from
Vamshi K Manda et al.
Phytotherapy research : PTR, 31(12), 1935-1945 (2017-10-27)
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The aim of this study was to evaluate the interactive effects of fluoxetine (FLU), roxithromycin (ROX) and propranolol (PRP) on the bioaccumulation and biochemical responses in the crucian carp Carassius auratus. After 7 days of binary exposure (ROX + FLU
Jiannan Ding et al.
Environmental pollution (Barking, Essex : 1987), 238, 1-9 (2018-03-13)
While the presence of microplastics (MPs) in marine environments has been detected worldwide, the importance of MPs pollution in freshwater environments has also been emphasized in recent years. However, the body of knowledge regarding the biological effects of MPs on
Guanghua Lu et al.
International journal of environmental research and public health, 15(11) (2018-11-02)
2-Ethylhexyl-4-dimethylaminobenzoate (EHDAB) is a commonly used organic ultraviolet filter. The bioaccumulation and biomagnification of EHDAB were investigated in two aquatic animals, the larvae of midge (Chironomus riparius) and crucian carp (Carassius carassius), and the metabolic enzyme responses in fish liver
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