AC-0341A

HSP70 (EP377) Rabbit Monoclonal Primary Antibody

• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• antibody form: Ig fraction of antiserum
• clone: monoclonal
• description: For In Vitro Diagnostic Use in Select Regions (See Chart)
• form: buffered aqueous solution
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: nuclear

Description

General description

The heat shock proteins (HSPs) are a conserved family of ubiquitously expressed proteins that functions to protect cells from various environmental damage. Two proteins within the family, HSP70 and HSP27 demonstrate strong anti-apoptotic activity; its overexpression allow cells to survive in variable conditions. HSPs have been implicated in tumorigenesis – affecting cell cycle regulation, multidrug resistance and modulating p53 function. HSP70 has been studied in a variety of malignancies, including breast, lung, oral, prostate and uterine-cervical cancers. A majority of results associated HSP70 overexpression with poor prognosis and resistance to therapy. Recently, HSP70 diagnostic utility was established in identifying hepatocellular carcinoma (HCC). HSP70 was the most abundantly up-regulated gene in advanced HCC and its immunoreactivity was seen in the majority of HCC. Its sensitivity and specificity were determined as 74% and 98%, respectively. Furthermore, a three antibody panel with HSP70, Glypican 3, and Glutamine Synthetase is capable of distinguishing HCC from high grade dysplastic nodules with 100% specificity when 2 markers are positive.

Quality

IVD

IVD

IVD

RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1%BSA and &< 0.1% Sodium Azide

Other Notes

For a copy of the IFU and CofA contact IVDorder@ABCAM.com

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable