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37970

Sigma-Aldrich

5,7-Dihydroxytryptamine creatinine sulfate salt

≥97.0% (HPLC)

Synonym(s):

5,7-DHT, 7-Hydroxyserotonin creatinine sulfate salt

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About This Item

Empirical Formula (Hill Notation):
C10H12N2O2 · C4H7N3O · H2SO4
CAS Number:
39929-27-6
Molecular Weight:
403.41
Beilstein:
8817524
MDL number:
MFCD06198886
UNSPSC Code:
12352200
PubChem Substance ID:
57649784

Assay

≥97.0% (HPLC)

shipped in

wet ice

storage temp.

−20°C

SMILES string

OS(O)(=O)=O.CN1CC(=O)N=C1N.NCCc2c[nH]c3c(O)cc(O)cc23

InChI

1S/C10H12N2O2.C4H7N3O.H2O4S/c11-2-1-6-5-12-10-8(6)3-7(13)4-9(10)14;1-7-2-3(8)6-4(7)5;1-5(2,3)4/h3-5,12-14H,1-2,11H2;2H2,1H3,(H2,5,6,8);(H2,1,2,3,4)

InChI key

BXYXUOWJXUUTQZ-UHFFFAOYSA-N

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Biochem/physiol Actions

Neurotoxin that is relatively selective for serotonergic terminals in adults and gives long-lasting destruction of serotonergic neurons when given neonatally; adrenergic neurotoxicity can be blocked by pretreating with desipramine.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302 + H312 + H332

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCBG3656V
BCBB5803V
BCBB5803
BCBB1060
1434821

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Hai Lin et al.
Neuroscience letters, 598, 91-95 (2015-05-20)
Although tianeptine, an atypical antidepressant has been reported to have antinociceptive effects, the mode of action is different from that of tricyclic antidepressants despite structural similarities. We examined the antiallodynic effect of intrathecal tianeptine in neuropathic pain rats and determined
Victoria M Smith et al.
The European journal of neuroscience, 42(10), 2805-2817 (2015-10-13)
Light serves as the primary stimulus that synchronizes the circadian clock in the suprachiasmatic nucleus (SCN) to the external day/night cycle. Appropriately timed light exposure can reset the phase of the circadian clock. Some serotonergic drugs that bind to the
Amandine Dupuis et al.
Pharmacological research, 118, 93-103 (2016-09-25)
Antidepressants are one of the first line treatments for neuropathic pain but their use is limited by the incidence and severity of side effects of tricyclics and the weak effectiveness of selective serotonin reuptake inhibitors (SSRIs). Serotonin type 2A (5-HT
F Schwaller et al.
Scientific reports, 7(1), 2215-2215 (2017-05-24)
Descending connections from brainstem nuclei are known to exert powerful control of spinal nociception and pain behaviours in adult mammals. Here we present evidence that descending serotonergic fibres not only inhibit nociceptive activity, but also facilitate non-noxious tactile activity in
Lining Cao et al.
Frontiers in cellular neuroscience, 11, 131-131 (2017-05-24)
In the brain, the serotonergic neurons located in the raphe nucleus are the unique resource of the neurotransmitter serotonin, which plays a pivotal role in the regulation of brain development and functions. Dysfunction of the serotonin system is present in
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