Blasticidine S hydrochloride should be soluble in water at a concentration of 5 - 10 mg/mL. It is also soluble in acetic acid (concentration not reported).
15205
Blasticidine S hydrochloride
Blasticidine S hydrochloride
Synonym(s):
Blasticidin S
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About This Item
Empirical Formula (Hill Notation):
C17H26N8O5 · HCl
CAS Number:
Molecular Weight:
458.90
MDL number:
UNSPSC Code:
51102829
PubChem Substance ID:
NACRES:
NA.76
Pricing and availability is not currently available.
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form
powder
Quality Level
color
white to off-white
solubility
acetic acid: water: soluble, clear, colorless
antibiotic activity spectrum
fungi
application(s)
agriculture
environmental
Mode of action
protein synthesis | interferes
shipped in
dry ice
storage temp.
−20°C
SMILES string
Cl[H].CN(CC[C@@H](N)CC(=O)N[C@H]1C=C[C@@H](O[C@@H]1C(O)=O)N2C=CC(N)=NC2=O)C(N)=N
InChI
1S/C17H26N8O5.ClH/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29;/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29);1H/t9-,10+,13-,14+;/m1./s1
InChI key
YQXYQOXRCNEATG-ZAYJLJTISA-N
General description
Blasticidin S belongs to the aminoacylnucleoside class of antibiotics. It inhibits protein synthesis in bacteria and eukaryotes.[1] It also has fungicidal properties and prevents rice blast disease.[2]
Chemical structure: nucleoside
Application
Blasticidin S is used as a selection agent for transformed cells that contain the resistance genes bls, bsr, or BSD. Blasticidiin S has been used to select HEK293-T cells with TLR-2 constructs and HEK-D5 cells [3][4]. It is also used to study protein synthesis at the level of peptide bond formation.
Biochem/physiol Actions
Blasticidin S inhibits hydrolysis of peptidyl-tRNA induced by release factors. It enhances the binding of tRNA to the large subunit of ribosomes and to an extent inhibits peptide bond formation.[1]
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. Storage class (TRGS 510): Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
related product
Product No.
Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 1 Oral
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Egor Svidritskiy et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(30), 12283-12288 (2013-07-05)
The antibiotic blasticidin S (BlaS) is a potent inhibitor of protein synthesis in bacteria and eukaryotes. We have determined a 3.4-Å crystal structure of BlaS bound to a 70S⋅tRNA ribosome complex and performed biochemical and single-molecule FRET experiments to determine
Rohini Garg et al.
Journal of immunology (Baltimore, Md. : 1950), 184(11), 5980-5987 (2010-05-05)
Vi capsular polysaccharide is a major virulence determinant of the human typhoid- causing pathogen Salmonella typhi; it is absent in nontyphoidal Salmonella serovars. We show in this study that through its specific interaction with the membrane recognition complex containing the
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In response to foreign and endogenous double-stranded RNA (dsRNA), protein kinase R (PKR) and ribonuclease L (RNase L) reprogram translation in mammalian cells. PKR inhibits translation initiation through eIF2α phosphorylation, which triggers stress granule (SG) formation and promotes translation of
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What is Product 15205, Blasticidine S hydrochloride, soluble in?
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How should aqueous solutions of Product 15205, Blasticidine S hydrochloride, be stored?
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Aqueous solutions of Blasticidine S hydrochloride should be stored in aliquots at -20°C. Aqueous solutions at a pH °C or for 6 to 8 weeks at -20°C. Avoid alkaline pH, and do not subject solutions to freeze-thaw cycles.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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