04632

N-Methyl-L-tyrosine

≥98% (HPLC)

• Synonym(s): (S)-3-(4-Hydroxyphenyl)-2-(methylamino)propionic acid, N-Me-Tyr-OH, Surinamine
• Empirical Formula (Hill Notation): C₁₀H₁₃NO₃
• CAS Number: 537-49-5
• Molecular Weight: 195.22
• Beilstein: 2646795
• EC Number: 208-670-8
• MDL number: MFCD00238322
• UNSPSC Code: 12352202
• PubChem Substance ID: 329747962

Properties

• Assay: ≥98% (HPLC)
• form: powder or crystals
• optical activity: [α]/D +16.0±1.0°, c = 1 in 1 M HCl
• composition: carbon, 60.7-62.3% ; nitrogen, 6.9-7.5%
• color: colorless to white
• application(s): cell analysis
• SMILES string: CN[C@@H](Cc1ccc(O)cc1)C(O)=O
• InChI: 1S/C10H13NO3/c1-11-9(10(13)14)6-7-2-4-8(12)5-3-7/h2-5,9,11-12H,6H2,1H3,(H,13,14)/t9-/m0/s1
• InChI key: AXDLCFOOGCNDST-VIFPVBQESA-N

Description

Application

N-Methyl-L-tyrosine was used in experiments as a control group to show that methylation of the imino group in N-p-phenylpropionyl-L-tyrosine eliminates its inhibitory effect on the firing of the giant neurone of the giant African snail.

Biochem/physiol Actions

N-Methyl amino acids play an important role in investigations on prevention or therapy of Alzheimer′s disease, neurofibrillary tangles or amyloid plaque are physiological characteristics of this disease and ?-amyloid(40) fibrillogenesis and disassembly of ?-amyloid(40) fibrils is inhibited by short ?-amyloid congeners containing N-methyl amino acids at alternate residue.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319
• Precautionary Statements: P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable