Skip to Content
Merck
All Photos(1)

Documents

SMB01344

Sigma-Aldrich

N-Methyl-4-pyridone-5-carboxamide

Synonym(s):

1,4-Dihydro-1-methyl-4-oxo-3-pyridinecarboxamide, 1,4-Dihydro-1-methyl-4-oxo-nicotinamide, 1-Methyl-1,4-dihydro-4-oxo-3-pyridinecarboxamide, 1-Methyl-4-pyridone-3-carboxamide, 1-Methyl-4-pyridone-5-carboxamide, 4-Py, 4PY, Me4PY, Met4PY, N1-Methyl-4-pyridone-3-carboxamide, N1-Methyl-4-pyridone-5-carboxamide

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C7H8N2O2
CAS Number:
769-49-3
Molecular Weight:
152.15
MDL number:
MFCD31726263
UNSPSC Code:
12352205
NACRES:
NA.77

Assay

≥95% (HPLC)

Quality Level

100

form

solid

InChI

1S/C7H8N2O2/c1-9-3-2-6(10)5(4-9)7(8)11/h2-4H,1H3,(H2,8,11)

InChI key

KTLRWTOPTKGYQY-UHFFFAOYSA-N

General description

N1-methyl-4-pyridone-5-carboxamide is involved in nicotinate and nicotinamide metabolism.

Application

Metabolomics research

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKCQ7019

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Aurélie Lenglet et al.
Toxins, 8(11) (2016-11-18)
N-methyl-2-pyridone-5-carboxamide (2PY, a major metabolite of nicotinamide, NAM) was recently identified as a uremic toxin. Recent interventional trials using NAM to treat high levels of phosphorus in end-stage renal disease have highlighted new potential uremic toxicities of 2PY. In the
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women.
Yoshino, et al.
Science (New York, N.Y.), 372, 1224-1229 (2021)
Renata Novak Kujundžić et al.
International journal of molecular sciences, 22(11) (2021-06-03)
The activity of nicotinamide N-methyltransferase (NNMT) is tightly linked to the maintenance of the nicotinamide adenine dinucleotide (NAD+) level. This enzyme catalyzes methylation of nicotinamide (NAM) into methyl nicotinamide (MNAM), which is either excreted or further metabolized to N1-methyl-2-pyridone-5-carboxamide (2-PY)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service