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About This Item
Empirical Formula (Hill Notation):
C6H14O6
CAS Number:
Molecular Weight:
182.17
Beilstein:
1721898
EC Number:
MDL number:
UNSPSC Code:
12352201
PubChem Substance ID:
NACRES:
NA.21
Recommended Products
biological source
plant
Quality Level
Assay
≥98% (GC)
form
powder
color
white
useful pH range
5.0-6.5 (25 °C, 182 g/L, (77 °F ))
mp
167-170 °C (lit.)
solubility
water: 100 mg/mL, clear, colorless
storage temp.
room temp
SMILES string
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
InChI
1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1
InChI key
FBPFZTCFMRRESA-KVTDHHQDSA-N
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General description
D-Mannitol, a naturally occurring six-carbon sugar alcohol or polyol, is found in plants such as algae, onions, grasses, and olives. It is considered safe due to its relatively lower glycemic index than sucrose.
Application
D-Mannitol has been used:
- in osmotic loading to adjust the osmolarity of solutions
- as a component of test sugar solution for cellobiose-mannitol permeability test
- as an internal standard in nuclear magnetic resonance (NMR) to compare/analyze the mannitol concentrations in urine samples
- to treat the control cells and regulate the osmotic pressure of high glucose
D-mannitol has been used as a hydroxyl radical scavenger and as a medium supplement.
Biochem/physiol Actions
D-Mannitol may play an important role in lipolysis and fat oxidation as it can enhance the phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase 1 (ACC). It serves as an anti-obesity supplement. D-Mannitol stimulates the synthesis of short-chain fatty acids (SCFAs), which regulate lipid metabolism in the liver.
A sugar alcohol sweet tastant. Used in sweetness inhibition studies.
Other Notes
To gain a comprehensive understanding of our extensive range of Sugar alcohols for your research, we encourage you to visit our Carbohydrates Category page.
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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To define whether coughing during mannitol challenge is a nonspecific side effect of this challenge or is associated with asthma. A prospective study. University hospital. Thirty-seven steroid-naive, asthmatic subjects and 10 healthy subjects. The participants completed a symptom questionnaire, recorded
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Bronchiectasis is characterised by excessive production of mucus and pulmonary exacerbations. Inhaled osmotic agents may enhance mucociliary clearance, but few long-term clinical trials have been conducted. To determine the impact of inhaled mannitol on exacerbation rates in patients with non-cystic
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