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H159

Supelco

Heroin

analytical standard, ≥98% (HPLC)

Synonym(s):

Diacetylmorphine

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About This Item

Empirical Formula (Hill Notation):
C21H23NO5
CAS Number:
561-27-3
Molecular Weight:
369.41
EC Number:
209-217-7
MDL number:
MFCD00468072
UNSPSC Code:
41116107
PubChem Substance ID:
329815171
NACRES:
NA.24

grade

analytical standard

Quality Level

100

Assay

≥98% (HPLC)

form

powder

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

storage condition

desiccated

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

white to beige

solubility

H2O: <0.2 mg/mL
DMSO: 5 mg/mL, clear
ethanol: 6 mg/mL
0.1 M HCl: <6.67 mg/mL

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

CN1CC[C@]23[C@H]4Oc5c(OC(C)=O)ccc(C[C@@H]1[C@@H]2C=C[C@@H]4OC(C)=O)c35

InChI

1S/C21H23NO5/c1-11(23)25-16-6-4-13-10-15-14-5-7-17(26-12(2)24)20-21(14,8-9-22(15)3)18(13)19(16)27-20/h4-7,14-15,17,20H,8-10H2,1-3H3/t14-,15+,17-,20-,21-/m0/s1

InChI key

GVGLGOZIDCSQPN-PVHGPHFFSA-N

Related Categories

General description

Heroin is a highly addictive illicit drug and opioid agonist, widely used in medical applications as an analgesic.

Application

Heroin may be used as a standard to determine the amount of heroin present in clandestine heroin samples using capillary zone electrophoresis (CZE) technique. Heroin may be used as an analytical reference standard for the quantification of the analyte in biological samples using different chromatography techniques.
Heroin may be used as a standard to determine the amount of heroin present in clandestine heroin samples using capillary zone electrophoresis (CZE) technique.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300 + H310 + H330

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000341823
0000341823
0000240298
0000182100
025M4605V

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Joanne Neale et al.
Addiction (Abingdon, England), 114(4), 708-718 (2018-11-27)
Providing take-home naloxone (THN) to people who use opioids is an increasingly common strategy for reversing opioid overdose. However, implementation is hindered by doubts regarding the ability of people who use opioids to administer naloxone and respond appropriately to overdoses.
Ella Dilkes-Frayne et al.
The International journal on drug policy, 44, 164-173 (2017-06-06)
Addiction is generally understood to be characterised by a persistent pattern of regular, heavy alcohol and other drug consumption. Current models of addiction tend to locate the causes of these patterns within the body or brain of the individual, sidelining
Julie Netherland et al.
Culture, medicine and psychiatry, 40(4), 664-686 (2016-06-09)
The past decade in the U.S. has been marked by a media fascination with the white prescription opioid cum heroin user. In this paper, we contrast media coverage of white non-medical opioid users with that of black and brown heroin
Diacetylmorphine degradation to 6-monoacetylmorphine and morphine in cell culture: implications for in vitro studies
Hutchinson.RM, et al.
European Journal of Pharmacology, 453(1), 27-32 (2002)
Jennifer A Martin et al.
Nature communications, 10(1), 4140-4140 (2019-09-14)
Persistent transcriptional and morphological events in the nucleus accumbens (NAc) and other brain reward regions contribute to the long-lasting behavioral adaptations that characterize drug addiction. Opiate exposure reduces the density of dendritic spines on medium spiny neurons of the NAc;
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Protocols

HPLC Analysis of Drugs on Ascentis® Express HILIC

Analytical standards for drug analysis including heroin, cocaine, amphetamine, and methylenedioxymethamphetamine.

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