92826

Disodium (2RS)-2-hydroxyadipate

analytical standard

• Synonym(s): α-Hydroxyadipic acid disodium salt, (2RS)-2-Hydroxyadipic acid disodium salt, 2-Hydroxyhexanedioic acid disodium salt
• Empirical Formula (Hill Notation): C₆H₈Na₂O₅
• Molecular Weight: 206.10
• UNSPSC Code: 12352200
• PubChem Substance ID: 329770177
• NACRES: NA.24

Properties

• grade: analytical standard
• Quality Level: 100
• Assay: ≥94.0% (GC)
• shelf life: limited shelf life, expiry date on the label
• application(s): clinical testing
• format: neat

Description

Biochem/physiol Actions

2-Hydroxyadipic acid is a hydroxy-dicarboxylic acid formed by the reduction of 2-ketoadipic acid. Deficiency of 2-ketoadipic dehydrogenase causes 2-ketoadipic academia, a condition characterized by accumulation and excretion of 2-hydroxyadipic acid. A method involving derivatization and combined gas chromatography-mass spectrometry has been recently developed to separate the enantiomers of 3-hydroxyadipic acid. It has been shown that 3-hydroxyadipic acid excreted in urine consists of at least 95% of the L-enantiomer. This finding supports the hypothesis that dicarboxylic acids are degraded by ordinary beta-oxidation, and indicates that adipic acid may be converted into succinic acid.

Analysis Note

may contain ethanol

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable