Heptafluorobutyric anhydride is a perfluoroacylated acylation reagent, that forms stable, volatile derivatives with alcohols, amines, and phenols. It is majorly used to prepare electron-capturing derivatives for GC/electron capture detection. It is generally used with an acid scavenger, to help drive the reaction to completion and to prevent column damage from acidic by-products of the derivatization reaction. It is also used for the frequent testing of drugs of abuse such as, amphetamines and phencyclidine by GC-MS technique.
Clear borosilicate glass, high hydrolytic resistance (Type I)
Analysis Note
Suitable for derivatization of aldosterone, digoxin, digitoxin and metabolites, estradiol, postaglandins F1α and F2α, 3-oxo-Δ4-steroids, steroids and testosterone.
Other Notes
HFAA acylates amines, amino acids and other compounds. HFBA derivatives are highly volatile: used in GC separation[1][2]
Reagent for 3-enol heptafluorobutyrate, heptafluorobutyrate, heptafluorobutyryl, 17-heptafluorobutyryl and 17-heptafluorobutyrate.
Legal Information
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
Journal of pharmaceutical and biomedical analysis, 70, 557-562 (2012-06-05)
Antidepressant drugs are widely used for the treatment of depression and other psychiatric disorders and as a result they are involved in numerous clinical and forensic cases. The aim of this study was the development, optimization and validation of a
Urinary concentrations of the beta-antagonist oxprenolol and some of its major human metabolites were determined following oral administration of a dose of 160 mg to five fasted horses. Quantitation was performed by gas chromatography-mass spectrometry (GC-MS) in the selected ion
Rapid communications in mass spectrometry : RCM, 13(5), 376-380 (1999-04-21)
A gas chromatography/mass spectrometry (GC/MS) method is described which uses negative ion chemical ionization (NCI) and tandem mass spectrometry (MS/MS) for the determination of eight anabolic steroids in human urine. Eight anabolic steroids were derivatized by heptafluorobutyric anhydride (HFBA), and
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