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Millipore

Astragaloside IV

>98.0%

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About This Item

Empirical Formula (Hill Notation):
C41H68O14
CAS Number:
84687-43-4
Molecular Weight:
784.97
MDL number:
MFCD16036240
UNSPSC Code:
41106200
PubChem Substance ID:
329765850
NACRES:
NA.85

Quality Level

100

Assay

≥98.0% (TLC)
>98.0%

form

powder

mp

295-296 °C (lit.)

SMILES string

CC(C)(O)[C@@H]1CC[C@@](C)(O1)[C@H]2[C@@H](O)C[C@@]3(C)[C@@H]4C[C@H](O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@H]6C(C)(C)[C@H](CC[C@@]67C[C@@]47CC[C@]23C)O[C@@H]8OC[C@@H](O)[C@H](O)[C@H]8O

InChI

1S/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24-,25-,26-,27+,28-,29+,30+,31-,32-,33-,34+,37+,38-,39+,40-,41+/m0/s1

InChI key

QMNWISYXSJWHRY-YLNUDOOFSA-N

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Biochem/physiol Actions

Anti-inflammatory.

Other Notes

Chemical constituent of Astragali radix

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCB3090
BCCB2207
BCBX5957
BCBS9602V
BCBR2507V

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Sigma-Aldrich

282200

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Ginsenoside Rb1 European Pharmacopoeia (EP) Reference Standard

Y0001347

Ginsenoside Rb1

Fucoidan from Fucus vesiculosus ≥95%

Sigma-Aldrich

F8190

Fucoidan from Fucus vesiculosus

Ming Hao et al.
Zhonghua yi xue za zhi, 92(30), 2104-2107 (2012-11-20)
To explore the protective effects of astragaloside IV on retinal ganglion cells (RGC) incubated under high glucose. Cultured RGC-5 were divided into 3 groups: control, high glucose and high glucose+astragaloside IV. The survival rate of cell was measured by CCK-8
Li-feng Huang et al.
Fitoterapia, 83(8), 1514-1522 (2012-09-18)
High mobility group box 1 protein (HMGB1), a potent pro-inflammatory cytokine, contributes to the pathogenesis of diverse inflammatory and infectious disorders. Some studies have illustrated the potential effect of HMGB1 on regulatory T cells (Tregs). Astragaloside IV (AST IV) isolated
I. Kitagawa et al.
Chemical & Pharmaceutical Bulletin, 31, 698-698 (1983)
Rui-Na Zhou et al.
Drug metabolism and pharmacokinetics, 27(6), 586-597 (2012-06-08)
Astragaloside IV (AIV) is the most abundant saponin and a marker compound in Astragali Radix, a Chinese herb notable for its anti-aging and immune-enhancing effects. The present study investigated the role of intestinal bacterial conversion in the in vivo fate
Xiaoyan Gu et al.
Molecular medicine reports, 6(1), 115-120 (2012-04-17)
Astragaloside IV (AS-IV) has been noted for its reduction of eosinophilic airway inflammation in a murine model of chronic asthma. To gain a better understanding of the mechanisms involved in this anti-inflammatory phenomenon, the effect of AS-IV on human blood
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