Interleukin-10 (IL-10), originally known as Cytokine Synthesis Inhibitory Factor (CSIF) is an 18.7 kDa protein of 160 amino acid residues that shares over 80% sequence homology with the Epstein-Barr Virus protein BCRFI. IL-10 down regulates the expression of Th1 cytokines, major histocompatibility complex class II antigens, and costimulatory molecules on macrophages. It also enhaces B cell survival, proliferation, and antibody production. Knockout studies suggest that IL-10 is an immunoregulator in the intestinal tract.
Immunogen
GST-tagged recombinant protein corresponding to mouse Interleukin-10.
Application
Detect Interleukin-10 using this Anti-Interleukin-10 Antibody validated for use in WB.
Quality
Evaluated by Western Blot in mouse Interleukin-10 recombinant protein.
Western Blot Analysis: 0.01 µg/mL of this antibody detected Interleukin-10 on 10 µg of mouse Interleukin-10 recombinant protein.
Target description
~18 kDa observed.
Analysis Note
Control Mouse Interleukin-10 recombinant protein
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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United European gastroenterology journal, 6(3), 446-453 (2018-05-19)
Inflammatory bowel diseases are consequence of an intestinal homeostasis breakdown in which innate immune dysregulation is implicated. Toll-like receptor (TLR)2 and TLR4 are immune recognition receptors expressed in the intestinal epithelium, the first physical-physiological barrier for microorganisms, to inform the
Exercise ameliorates high fat diet induced cardiac dysfunction by increasing interleukin 10.
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