612080
TIMP-1
≥90% (SDS-PAGE), liquid, MMP inhibitor, Calbiochem®
Synonym(s):
Tissue Inhibitor of Metalloproteinase-1
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.77
Recommended Products
product name
TIMP-1, Human Neutrophil Granulocyte, Native TIMP-1 from human granulocyte.
Quality Level
Assay
≥90% (SDS-PAGE)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
shipped in
wet ice
storage temp.
−70°C
General description
Native TIMP-1 from human granulocyte. Member of a family of inhibitors that participate in the activation and regulation of MMP activity. Forms a non-covalent stochiometric complex with latent and active MMPs. Binds to pro-MMP-9 and MMP-9 via their C-terminal domains.
Native TIMP-1 from human granulocyte. Member of a family of inhibitors that participate in the activation and regulation of MMP activity. Forms a non-covalent stoichiometric complex with latent and active MMPs. Binds to pro-MMP-9 and MMP-9 via their C-terminal domains.
Biochem/physiol Actions
Cell permeable: no
Primary Target
MMP activity
MMP activity
Product does not compete with ATP.
Reversible: no
Packaging
Please refer to vial label for lot-specific concentration.
Warning
Toxicity: Standard Handling (A)
Physical form
In 200 mM NaCl, 50 mM Tris-HCl, 5 mM CaCl₂, 1 µM ZnCl₂, 0.05% BRIJ® 35 Detergent, 0.05% NaN₃, pH 7.0.
Preparation Note
Prepared from stimulated neutrophils that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Reconstitution
Following initial thaw, aliquot and freeze (-70°C).
Other Notes
Kolkenbrock, H., et al. 1996. Biol. Chem. 377, 529.
Kolkenbrock, H., et al. 1995. Biol. Chem. Hoppe Seyler 376, 495.
Kolkenbrock, H., et al. 1995. Biol. Chem. Hoppe Seyler 376, 495.
Legal Information
Brij is a registered trademark of Croda International PLC
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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