A cell-permeable selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC50 = 70 nM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target PDE 3
Product does not compete with ATP.
Reversible: no
Target IC50: 70 nM against PDE III
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
Other Notes
Verghese, M.W., et al. 1995. J. Pharmacol. Exp. Ther. 272, 1313. Christensen, S.B., and Trophy, T.J. 1994. Ann. Rep. Med. Chem. 29, 185. Tang, K.M., et al. 1994. Eur. J. Pharmacol. 268, 105.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Journal of visualized experiments : JoVE, (172) (2021-07-06)
Events associated with oocyte nuclear maturation have been well described. However, much less is known about the molecular pathways and processes that take place in the cytoplasm in preparation for fertilization and acquisition of totipotency. During oocyte maturation, changes in
Overexpression of forkhead transcription factor FOXC2 in white adipose tissue (WAT) leads to a lean phenotype resistant to diet-induced obesity. This is due, in part, to enhanced catecholamine-induced cAMP-PKA signaling in FOXC2 transgenic mice. Here we show that rolipram treatment
Human reproduction (Oxford, England), 22(5), 1239-1246 (2007-02-17)
The use of hormones for controlled ovarian stimulation results in follicular heterogeneity, with oocytes at diverse stages of nuclear and cytoplasmic development. This study evaluated the impact of temporary nuclear arrest by a specific phosphodiesterase 3-inhibitor (PDE3-I), cilostamide, on nuclear
Development (Cambridge, England), 151(11) (2024-05-24)
The RNA-binding protein cytoplasmic polyadenylation element binding 1 (CPEB1) plays a fundamental role in regulating mRNA translation in oocytes. However, the specifics of how and which protein kinase cascades modulate CPEB1 activity are still controversial. Using genetic and pharmacological tools
During oocyte maturation, changes in gene expression depend exclusively on translation and degradation of maternal mRNAs rather than transcription. Execution of this translation program is essential for assembling the molecular machinery required for meiotic progression, fertilization, and embryo development. With
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