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810253P

Avanti

dehydroergosterol (DHE)

ergosta-5,7,9(11),22-tetraen-3β-ol, powder

Synonym(s):

DHE

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About This Item

Empirical Formula (Hill Notation):
C28H42O
CAS Number:
516-85-8
Molecular Weight:
394.63
MDL number:
MFCD00083319
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (with stopper and crimp cap (810253P-1mg))

manufacturer/tradename

Avanti Research™ - A Croda Brand 810253P

shipped in

dry ice

storage temp.

−70°C

SMILES string

O[C@H]1CC[C@]2(C(=CC=C3[C@H]4[C@@]([C@H](CC4)[C@H](C)\C=C\[C@@H](C(C)C)C)(CC=C32)C)C1)C

InChI

1S/C28H42O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h7-10,14,18-20,22,24-25,29H,11-13,15-17H2,1-6H3/b8-7+/t19-,20+,22-,24+,25-,27-,28+/m0/s1

InChI key

QSVJYFLQYMVBDR-CMNOFMQQSA-N

General description

Dehydroergosterol (DHE) is a fluorescent sterol that possesses similar biophysical properties as cholesterol. It is found in yeast cells and other fungi.

Application

Dehydroergosterol (DHE) is suitable for the transfer of DHE from a population of donor (LD) to acceptor (LA) liposomes.

Biochem/physiol Actions

Dehydroergosterol (DHE) is used for the visualization of intracellular traffic and intracellular transport kinetics.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (810253P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Molecular basis for sterol transport by StART-like lipid transfer domains
Horenkamp FA, et al.
The Embo Journal, 37(6) (2018)
Reynold Homan et al.
Analytical biochemistry, 441(1), 80-86 (2013-07-16)
We describe a simple but sensitive fluorescence method to accurately detect the esterification activity of lecithin:cholesterol acyltransferase (LCAT). The new assay protocol employs a convenient mix, incubate, and measure scheme. This is possible by using the fluorescent sterol dehydroergosterol (DHE)
Mohsen Pourmousa et al.
The journal of physical chemistry. B, 118(26), 7345-7357 (2014-06-04)
Although dehydroergosterol (DHE) is one of the most commonly used cholesterol (CHOL) reporters, it has remained unclear why it performs well compared with most other CHOL analogues and what its possible limitations are. We present a comprehensive study of the
Luís M B B Estronca et al.
Journal of lipid research, 55(6), 1033-1043 (2014-04-09)
The rate of noncatalyzed transfer of cholesterol (Chol) among lipoproteins and cells in the blood is of fundamental importance as a baseline to assess the role of active transport mechanisms, but remains unknown. Here we address this gap by characterizing
Frederick R Maxfield et al.
Methods in cell biology, 108, 367-393 (2012-02-14)
Cholesterol plays an important role in determining the biophysical properties of biological membranes, and its concentration is tightly controlled by homeostatic processes. The intracellular transport of cholesterol among organelles is a key part of the homeostatic mechanism, but sterol transport
View All Related Papers

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