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193941

Sigma-Aldrich

4-Chlorophenoxyacetyl chloride

98%

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About This Item

Linear Formula:
ClC6H4OCH2COCl
CAS Number:
4122-68-3
Molecular Weight:
205.04
EC Number:
223-923-2
MDL number:
MFCD00000727
UNSPSC Code:
12352100
PubChem Substance ID:
24851623
NACRES:
NA.22

Assay

98%

refractive index

n20/D 1.5486 (lit.)

bp

142 °C/17 mmHg (lit.)

mp

18.8 °C (lit.)

density

1.314 g/mL at 25 °C (lit.)

SMILES string

ClC(=O)COc1ccc(Cl)cc1

InChI

1S/C8H6Cl2O2/c9-6-1-3-7(4-2-6)12-5-8(10)11/h1-4H,5H2

InChI key

VRBVHQUSAOKVDH-UHFFFAOYSA-N

Application

4-Chlorophenoxyacetyl chloride was used in the preparation of:
  • substituted acetophenone derivatives
  • 2-(4-chlorophenoxyacetylamino)-3-ethoxycarbonyl[2,3-b]quinuclidine
  • 2-(4-chlorophenoxy)-N′-[2-(4-chlorophenoxy)acetyl]acetohydrazide monohydrate

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Ting Chen et al.
Acta crystallographica. Section E, Structure reports online, 66(Pt 11), o2829-o2829 (2010-01-01)
In the title compound, C(16)H(14)Cl(2)N(2)O(4)·H(2)O, the hydrazine and water mol-ecules are both located on twofold axes. The C-N-N-C torsion angle is -72.66 (1)° and the dihedral angle between the two benzene rings is 67.33 (1)°. In the crystal, mol-ecules are linked into
Jonathan Rosen et al.
Organic letters, 9(4), 667-669 (2007-01-27)
A direct and efficient method was developed for the preparation of a variety of substituted acetophenone derivatives from readily available arene precursors and acid chlorides. This method has significant generality and affords access to substitution patterns on aryl rings not
Synthesis and properties of 2-amino-3-ethycarbonylthieno [2, 3-b] quinuclidines.
Kaminka ME, et al.
Pharmaceutical Chemistry Journal, 21(8), 568-570 (1987)

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