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V0130

Sigma-Aldrich

[Arg8]-Vasotocin acetate salt

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C43H67N15O12S2
CAS Number:
74927-14-3
Molecular Weight:
1050.22
MDL number:
MFCD00133923
UNSPSC Code:
51111800
PubChem Substance ID:
24900689
NACRES:
NA.32

Quality Level

200

Assay

≥97% (HPLC)

solubility

H2O: soluble 20 mg/mL, clear, colorless

UniProt accession no.

P01185

storage temp.

−20°C

SMILES string

CC[C@@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O

InChI

1S/C43H67N15O12S2/c1-3-21(2)34-41(69)53-26(12-13-31(45)60)37(65)55-28(17-32(46)61)38(66)56-29(20-72-71-19-24(44)35(63)54-27(39(67)57-34)16-22-8-10-23(59)11-9-22)42(70)58-15-5-7-30(58)40(68)52-25(6-4-14-50-43(48)49)36(64)51-18-33(47)62/h8-11,21,24-30,34,59H,3-7,12-20,44H2,1-2H3,(H2,45,60)(H2,46,61)(H2,47,62)(H,51,64)(H,52,68)(H,53,69)(H,54,63)(H,55,65)(H,56,66)(H,57,67)(H4,48,49,50)/t21-,24+,25+,26+,27+,28+,29+,30+,34+/m1/s1

InChI key

OXDZADMCOWPSOC-QLWWDPKZSA-N

Gene Information

human ... AVP(551)

Amino Acid Sequence

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Arg-Gly-NH2 [Disulfide Bridge: 1-6]

Application

[Arg8]-Vasotocin acetate salt was used as a test compound for studying whether it can regulate the interspecific cooperative behaviour in fish. The product was used for inducing parturition in viviparous females to study reproduction in oviparous and viviparous lizard females of species Zootoca vivipara.

Biochem/physiol Actions

[Arg8]-Vasotocin (AVT) is a neurohypophyseal peptide of the vasopressin/oxytocin hormone family that mediates social behaviors, coregulates the adrenocortical stress response as well as maintains water balance. AVT stimulates neurones in the mammalian central nervous system.

Preparation Note

[Arg8]-Vasotocin acetate salt dissolves in water at 20 mg/ml to yield a clear, colorless solution.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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H Bobby Fokidis et al.
Brain, behavior and evolution, 79(2), 84-97 (2011-11-10)
The neuropeptide arginine vasotocin (AVT: the avian homolog of vasopressin) has numerous functional roles including mediating social behaviors, coregulating the adrenocortical stress response and maintaining water balance. These functions of AVT make it susceptible to environmental influence, yet little is
Saori Yokoi et al.
PLoS genetics, 11(2), e1005009-e1005009 (2015-02-27)
To increase individual male fitness, males of various species remain near a (potential) mating partner and repel their rivals (mate-guarding). Mate-guarding is assumed to be mediated by two different types of motivation: sexual motivation toward the opposite sex and competitive
H Hausmann et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(14), 6907-6912 (1996-07-09)
To identify determinants that form nonapeptide hormone binding domains of the white sucker Catostomus commersoni [Arg8]vasotocin receptor, chimeric constructs encoding parts of the vasotocin receptor and parts of the isotocin receptor have been analyzed by [(3,5-3H)Tyr2, Arg8]vasotocin binding to membranes
David Kabelik et al.
Brain, behavior and evolution, 72(4), 283-294 (2008-11-20)
The neuropeptide arginine vasotocin (AVT) and its mammalian homologue arginine vasopressin (AVP) are neuromodulators known to be steroid sensitive and associated with social behaviors in a number of vertebrate taxa. However, the role of AVT/P in the regulation of aggression
R Mihai et al.
Neuroscience, 62(3), 783-792 (1994-10-01)
The excitatory effect of [Arg8]-vasopressin and its potential contribution to the circadian cycle of electrical activity in the suprachiasmatic nucleus of the rat was investigated using extracellular recordings from hypothalamic slices from virgin female rats. The majority of neurons tested
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