Unfortunately, the stability of the solution for this product has not been determined.
SML0569
RO-3306
≥98% (HPLC), powder, CDK1 inhibitor
Synonym(s):
(5Z)-5-Quinolin-6-ylmethylene-2-[(thiophen-2-ylmethyl)-amino]-thiazol-4-one, 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone
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All Photos(3)
About This Item
Empirical Formula (Hill Notation):
C18H13N3OS2
CAS Number:
Molecular Weight:
351.45
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
Recommended Products
Product Name
RO-3306, ≥98% (HPLC)
Quality Level
Assay
≥98% (HPLC)
form
powder
color
off-white to brown
solubility
DMSO: 5 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C1N=C(NCC2=CC=CS2)S/C1=C\C3=CC4=C(C=C3)N=CC=C4
InChI
1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)/b16-10-
InChI key
XOLMRFUGOINFDQ-YBEGLDIGSA-N
Application
Biochem/physiol Actions
CDK1 (cyclin dependent kinase 1) is considered to be the “master switch” in cell division, which maintains the mitotic state of cells.[4]
RO-3306 is a selective ATP-competitive inhibitor of CDK1.
RO-3306 is a selective ATP-competitive inhibitor of CDK1. It inhibites CDK1 cyclin B1 activity with Ki of 35 nM, nearly 10-fold selectivity relative to CDK2/cyclin E and over 50-fold relative to CDK4/cyclin D. RO-3306 has been used to cause cell cycle arrest at the G2/M boundary.
Features and Benefits
This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Articles
Review properties, activators and inhibitors, and available products for researching cyclin-dependent kinases (CDKs).
Review properties, activators and inhibitors, and available products for researching cyclin-dependent kinases (CDKs).
Review properties, activators and inhibitors, and available products for researching cyclin-dependent kinases (CDKs).
Review properties, activators and inhibitors, and available products for researching cyclin-dependent kinases (CDKs).
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After dissolving the product, can i freeze my aliquots? If i can't freeze them, then how long is it viable at 4 degrees
1 answer-
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