S9072
Anti-SOX2 antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Sex-determining region Y-box 2
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About This Item
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 34-37 kDa
species reactivity
human, rat, mouse
concentration
~1 mg/mL
technique(s)
flow cytometry: 1:200-1:500
immunohistochemistry: 1:100-1:200
western blot: 1:500-1:1,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SOX2(6657)
mouse ... Sox2(20674)
rat ... Sox2(499593)
General description
Transcription factor SOX-2 (SOX-2) is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. Mutations in this gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation. When SOX-2 is expressed in self renewing progenitor cells, it acts to inhibit neuronal differentiation. Conversely, active repression of SOX-2 induces neural differentiation.
Specificity
Rabbit polyclonal anti-SOX2 antibody recognizes human, mouse, rat sex-determining region Y-box 2 transcription factors.
Immunogen
synthetic peptide corresponding to residues 32-47 of human SOX2.
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Western Blotting (1 paper)
Immunohistochemistry (1 paper)
Western Blotting (1 paper)
Rabbit polyclonal anti-SOX2 antibody is used to tag solute sex-determining region Y-box 2 transcription factor for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques, such as immunoblotting (~37 kDa) and flow cytometry. It is used as a probe to determine the presence and roles of sex-determining region Y-box 2 transcription factor in progenitor cell self renewal and differentiation.
Physical form
solution in phosphate buffered saline, containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Elisa Latorre et al.
Molecular pharmacology, 89(2), 243-252 (2015-12-18)
Since 2005, sex determining region y-box 2 (SOX2) has drawn the attention of the scientific community for being one of the key transcription factors responsible for pluripotency induction in somatic stem cells. Our research investigated the turnover regulation of SOX2
Bartolo Bono et al.
Scientific reports, 8(1), 13838-13838 (2018-09-16)
Cancer stem cells (CSCs) have been involved in the maintenance, progression and relapse of several tumors, but their origin is still elusive. Here, in vitro transformed human fibroblasts (cen3tel cells) and the tumorsphere assay were used to search for and
Dasa Dolezalova et al.
Stem cells (Dayton, Ohio), 30(7), 1362-1372 (2012-04-19)
Studies of human embryonic stem cells (hESCs) commonly describe the nonfunctional p53-p21 axis of the G1/S checkpoint pathway with subsequent relevance for cell cycle regulation and the DNA damage response (DDR). Importantly, p21 mRNA is clearly present and upregulated after
Mantas Matjusaitis et al.
Stem cell reports, 13(6), 1053-1067 (2019-11-12)
Cell lineage reprogramming via transgene overexpression of key master regulatory transcription factors has been well documented. However, the poor efficiency and lack of fidelity of this approach is problematic. Synthetic transcription factors (sTFs)-built from the repurposed CRISPR/Cas9 system-can activate endogenous
Martyna Łupicka et al.
Reproductive biology and endocrinology : RB&E, 13, 110-110 (2015-09-30)
Adenomyosis is a proliferative uterine dysfunction with unknown aetiology. One possible mechanism of its development involves disturbances in stem cell differentiation in uterine tissue. Previously, we identified pluripotent/multipotent cells in the bovine uterus, therefore our present study focused on determining
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