C9538

Coenzyme Q₁₀

≥98% (HPLC), powder, antioxidant

• Synonym(s): CoQ10, Q-10, Ubiquinone 50, Ubiquinone-10
• Empirical Formula (Hill Notation): C₅₉H₉₀O₄
• CAS Number: 303-98-0
• Molecular Weight: 863.34
• Beilstein: 1900141
• EC Number: 206-147-9
• MDL number: MFCD00042919
• UNSPSC Code: 12352200
• PubChem Substance ID: 24893170
• NACRES: NA.77

Properties

• product name: Coenzyme Q₁₀, ≥98% (HPLC)
• Assay: ≥98% (HPLC)
• form: powder
• color: yellow to dark orange
• mp: 49 °C
• application(s): cell analysis
• storage temp.: −20°C
• SMILES string: O=C(C(OC)=C1OC)C(C/C=C(C)/CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)\C)\C)\C)\C)\C)=C(C)C1=O
• InChI: 1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
• InChI key: ACTIUHUUMQJHFO-UPTCCGCDSA-N

Description

General description

Coenzyme Q (CoQ), also known as ubiquinone, is a lipid-soluble antioxidant and is an essential component of the mitochondrial electron transport chain. The molecule contains a biologically active quinone with a benzoquinone ring and an isoprenoid sidechain. Q10 is synthesized in the cytoplasm and mitochondria () which generates ATP through aerobic cellular respiration. CoQ10 is required for the optimal functioning of the immune system and for cardiovascular health (). The ability to repress inflammatory gene expression exhibits its anti-inflammatory property ( ) Genetic failure or ageing results in CoQ10 deficiency, indicated by suppression of immune function. ()

Application

Coenzyme Q10 (CoQ10) has been used:

• as a bioactive compound to study its immune modulating properties in vitro
• as a standard for high-performance liquid chromatography
• to study its effect on exercised rat aorta
• in the cellular CoQ uptake assay

Biochem/physiol Actions

Coenzyme Q10 is an endogenous cellular antioxidant and an essential component of the electron transfer chain. CoQ10 takes part in aerobic cellular respiration and generation of energy in the form of ATP.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves