91893

Poly(ethylene glycol)

BioUltra, 400

• Synonym(s): Polyethylene glycol, PEG
• Linear Formula: H(OCH₂CH₂)_nOH
• CAS Number: 25322-68-3
• MDL number: MFCD00081839
• UNSPSC Code: 12352104
• PubChem Substance ID: 24889578
• NACRES: NA.26

Properties

• product line: BioUltra
• form: liquid
• mol wt: M_r 380-420
• impurities: insoluble matter:, passes filter test; ≤0.02% peroxides (as H₂O₂):
• refractive index: n20/D 1.467
• pH: 5.5-7.0 (25 °C, 50 mg/mL in H₂O)
• solubility: H₂O: 50 mg/mL at 25 °C, clear, colorless
• density: 1.126 g/mL at 20 °C
• anion traces: chloride (Cl^-): ≤50 mg/kg; sulfate (SO₄^2-): ≤50 mg/kg
• cation traces: Al: ≤5 mg/kg; As: ≤0.1 mg/kg; Ba: ≤5 mg/kg; Bi: ≤5 mg/kg; Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤200 mg/kg; Li: ≤5 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: ≤300 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: ≤5 mg/kg
• λ: 50 mg/mL in H₂O
• UV absorption: λ: 260 nm A_max: 0.06; λ: 280 nm A_max: 0.03
• SMILES string: C(CO)O
• InChI: 1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
• InChI key: LYCAIKOWRPUZTN-UHFFFAOYSA-N

Description

General description

Poly(ethylene glycol) (PEG) is a non-ionic hydrophilic polymer and is available in different molecular weights. It facilitates the purification and crystal growth of proteins and nucleic acids. PEG and dextran together result in aqueous polymer two phase system, which is required for the purification of biological materials. PEG also interacts with cell membrane, thereby allowing cell fusion.

Application

Poly(ethylene glycol) (PEG) has been used to dissolve JC-124, nucleotide-binding domain, leucine rich family pyrin containing 3 gene (NLRP3) inflammasome inhibitor and solubilize CoQ₁₀, a mitochondrial coenzyme Q₄.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves