341492

FeTPPS

A ferric porphyrin complex that catalytically isomerizes peroxynitrite to nitrate both in vivo and in vitro.

• Synonym(s): FeTPPS, 5,10,15,20-Tetrakis(4-sulfonatophenyl)porphyrinato Iron (III), Chloride
• Empirical Formula (Hill Notation): C₄₄H₂₈ClFeN₄O₁₂S₄
• Molecular Weight: 1024.27
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: dark brown
• solubility: water: soluble
• shipped in: ambient
• storage temp.: 2-8°C

Description

General description

A ferric porphyrin complex that catalytically isomerizes peroxynitrite to nitrate both in vivo and in vitro. Hence, serves as a selective peroxynitrite scavenger and decomposition catalyst. Provides cytoprotection against peroxynitrite (EC₅₀ = 5 µM). Does not complex with nitric oxide and exhibits minimal SOD mimetic activity.

A ferric porphyrin complex that catalytically isomerizes peroxynitrite to nitrate both in vivo and in vitro. Provides cytoprotection against peroxynitrite (EC₅₀ = 5 µM). Does not complex with nitric oxide and exhibits minimal SOD mimetic activity.

Biochem/physiol Actions

Cell permeable: no

EC50 = 5 µM for cytoprotection against peroxynitrite

Primary Target
Selective peroxynitrite scavenger

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.

Other Notes

Imam, S.Z., et al. 2000. Ann. N.Y. Acad. Sci.914, 157.
Misko, T.P., et al. 1998. J. Biol. Chem. 273, 15646.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable