A cell-permeable, reversible inhibitor of nitric oxide synthase in vitro (IC50 = 2-3 µM) and in vivo. Causes dose-dependent vasoconstriction and bradycardic effects.
Endogenous reversible inhibitor of nitric oxide synthesis in vitro and in vivo. Causes dose-dependent vasoconstriction and bradycardic effects.
Biochem/physiol Actions
Cell permeable: yes
Primary Target NOS in vitro
Product does not compete with ATP.
Reversible: yes
Target IC50: 2-3 µM inhibiting nitric oxide synthase in vitro
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Other Notes
Closs, E.I., et al. 1997. Nitric Oxide1, 65. Faraci, F.M., et al. 1995. Am. J. Physiol.269, H1522. Gardiner, S.M., et al. 1993. Br. J. Pharmacol. 110, 1457. Kotani, K., et al. 1992. J. Neurochem.58, 1127. Vallance, P., et al. 1992. Lancet339, 572.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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