Subchronic tolerance trials of graded oral supplementation with ornithine hydrochloride or citrulline in healthy adults.: This research examines the safety and tolerance of varying doses of L-ornithine hydrochloride in healthy adults. The findings indicate that L-ornithine hydrochloride is well-tolerated at different dosage levels, making it a viable supplement for various applications (Miura et al., 2023).
Combined administration of ornithine and phenylacetate (OP) is proposed as a novel treatment of hyperammonemia and hepatic encephalopathy. Ornithine is believed to increase ammonia fixation into glutamine in muscle tissue and glutamine is subsequently thought to react with phenylacetate forming
Critical reviews in immunology, 32(6), 463-488 (2013-02-23)
The purpose of immunology is simple. Cure or prevent disease. M1/M2 is useful because it is simple. M1/M2 describes the two major and opposing activities of macrophages. M1 activity inhibits cell proliferation and causes tissue damage while M2 activity promotes
Nature chemical biology, 9(4), 277-283 (2013-02-26)
LysW has been identified as a carrier protein in the lysine biosynthetic pathway that is active through the conversion of α-aminoadipate (AAA) to lysine. In this study, we found that the hyperthermophilic archaeon, Sulfolobus acidocaldarius, not only biosynthesizes lysine through
Escherichia coli possesses two acyl ornithine aminotransferases, one catabolic (AstC) and the other anabolic (ArgD), that participate in L-arginine metabolism. Although only 58% identical, the enzymes have been shown to be functionally interchangeable. Here we have purified AstC and have
American journal of physiology. Heart and circulatory physiology, 305(5), H651-H666 (2013-06-25)
Reduced production of nitric oxide (NO) is one of the first indications of endothelial dysfunction and precedes overt cardiovascular disease. Increased expression of Arginase has been proposed as a mechanism to account for diminished NO production. Arginases consume l-arginine, the
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