T8516
Trifluoperazine dihydrochloride
≥99%, powder
Synonym(s):
10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine dihydrochloride
About This Item
Assay
≥99%
form
powder
color
white to off-white
mp
243 °C (dec.) (lit.)
solubility
ethanol: soluble 5 mg/mL
H2O: soluble 50 mg/mL, clear, colorless to yellow
DMSO: soluble
storage temp.
−20°C
SMILES string
Cl[H].Cl[H].CN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1
InChI
1S/C21H24F3N3S.2ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;;/h2-3,5-8,15H,4,9-14H2,1H3;2*1H
InChI key
BXDAOUXDMHXPDI-UHFFFAOYSA-N
Gene Information
human ... DRD2(1813) , DRD3(1814) , DRD4(1815) , HTR2A(3356) , HTR2C(3358)
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Application
- to inhibit clathrin-dependent endocytosis
- as a calmodulin kinase antagonist in cultured Aplysia californica neurons
- as a plasma membrane Ca2+-ATPase (PMCA) inhibitor in mouse duodenal tissues to block the transcellular active calcium flux
Biochem/physiol Actions
Features and Benefits
Preparation Note
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Muta. 2 - STOT RE 1 - STOT SE 3
Target Organs
Central nervous system, Eyes
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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