SML3133

Viloxazine hydrochloride

≥95% (HPLC)

• Synonym(s): 1. 2-(2-Ethoxyphenoxymethyl-2,3,5,6-tetrahydro-1,4-oxazine hydrochloride salt, 2-((2-Ethoxyphenoxy)methyl)morpholine hydrochloride, 2-(o-Ethoxyphenoxymethyl)morpholine hydrochloride, 2-[(2-Ethoxyphenoxy)methyl]morpholinium chloride, I.C.I. 58,834 HCl, ICI 58,834 HCl, SPN-812, Viloxazine HCl, rac Viloxazine HCl, rac Viloxazine hydrochloride
• Empirical Formula (Hill Notation): C₁₃H₁₉NO₃ · HCl
• CAS Number: 35604-67-2
• Molecular Weight: 273.76
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00661100
• Assay: ≥95% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CCOC1=C(OCC2OCCNC2)C=CC=C1.Cl
• InChI: 1S/C13H19NO3.ClH/c1-2-15-12-5-3-4-6-13(12)17-10-11-9-14-7-8-16-11;/h3-6,11,14H,2,7-10H2,1H3;1H
• InChI key: HJOCKFVCMLCPTP-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Orally active serotonin norepinephrine modulating agent (SNMA). Norepinephrine reuptake inhibitor (NRI), 5-HT2B antagonist, 5-HT2C agonist in vitro and in vivo.

Viloxazine (ICI 58,834) is an orally active serotonin norepinephrine modulating agent (SNMA) originally reported as a norepinephrine reuptake inhibitor (NRI) with antidepressant (ED10 from 0.3-1 mg/kg p.o. against reserpine-induced hypothermia in mice), while exhibiting less sedative efficacy (locomotor activity reduction ED10 from 3-10 mg/kg p.o. in mice) and no monoamine oxidase inhibitory potency. Viloxazine shows 5-HT2B antagonist and 5-HT2C agonist activity in vitro and increases extracellular 5-HT levels in the prefrontal cortex (PFC) in vivo, a brain area implicated in Attention deficit hyperactivity disorder (ADHD).

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable