SML1760

BAM15

≥98% (HPLC), powder, mitochondrial protonophore uncoupler

• Synonym(s): BAM 15, N5,N6-bis(2-Fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
• Empirical Formula (Hill Notation): C₁₆H₁₀F₂N₆O
• CAS Number: 210302-17-3
• Molecular Weight: 340.29
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00373912
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: BAM15, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: FC(C=CC=C1)=C1NC2=NC3=NON=C3N=C2NC4=CC=CC=C4F
• InChI: 1S/C16H10F2N6O/c17-9-5-1-3-7-11(9)19-13-14(20-12-8-4-2-6-10(12)18)22-16-15(21-13)23-25-24-16/h1-8H,(H,19,21,23)(H,20,22,24)
• InChI key: OEGJBRZAJRPPHL-UHFFFAOYSA-N

Description

Biochem/physiol Actions

BAM15 is a cell penetrant and potent uncoupler of oxidative phosphorylation in mitochondria that that does not depolarizes the plasma membrane. BAM15 protects mice from acute renal ischemic-reperfusion injury.

BAM15 is a cell penetrant and potent uncoupler of oxidative phosphorylation in mitochondria.

BAM15 increases mitochondrial respiration rate and is also found to be less cytotoxic compared to other protonophore uncouplers such as carbonyl cyanide p-trifluoromethoxyphenylhydrazone. Hindered oncogenic MAPK (mitogen-activated protein kinase ) signaling leads to BAM15 induced mitochondrial apoptotic pathway activation.

Safety Information

• hcodes: H413
• pcodes: P273 - P501
• Hazard Classifications: Aquatic Chronic 4
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable